Evidence map›Paper›PMID 37552061›Full record

ArticleRadiology2023

Assessing Quantitative Parenchymal Features at Baseline Dynamic Contrast-enhanced MRI and Cancer Occurrence in Women with Extremely Dense Breasts.

Hui Wang, Bas H M van der Velden, Erik Verburg, Marije F Bakker, Ruud M Pijnappel, Wouter B Veldhuis, Carla H van Gils, Kenneth G A Gilhuijs

Abstract read
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In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Hui WangFrom the Image Sciences Institute (H.W., B.H.M.v.d.V., E.V., K.G.A.G.), Julius Center for Health Sciences and Primary Care (M.F.B., C.H.v.G.), and Department of Radiology (R.M.P., W.B.V.), University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.ORCID 0000-0002-3961-1461
Bas H M van der VeldenFrom the Image Sciences Institute (H.W., B.H.M.v.d.V., E.V., K.G.A.G.), Julius Center for Health Sciences and Primary Care (M.F.B., C.H.v.G.), and Department of Radiology (R.M.P., W.B.V.), University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
Erik VerburgFrom the Image Sciences Institute (H.W., B.H.M.v.d.V., E.V., K.G.A.G.), Julius Center for Health Sciences and Primary Care (M.F.B., C.H.v.G.), and Department of Radiology (R.M.P., W.B.V.), University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
Marije F BakkerFrom the Image Sciences Institute (H.W., B.H.M.v.d.V., E.V., K.G.A.G.), Julius Center for Health Sciences and Primary Care (M.F.B., C.H.v.G.), and Department of Radiology (R.M.P., W.B.V.), University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
Ruud M PijnappelFrom the Image Sciences Institute (H.W., B.H.M.v.d.V., E.V., K.G.A.G.), Julius Center for Health Sciences and Primary Care (M.F.B., C.H.v.G.), and Department of Radiology (R.M.P., W.B.V.), University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
Wouter B VeldhuisFrom the Image Sciences Institute (H.W., B.H.M.v.d.V., E.V., K.G.A.G.), Julius Center for Health Sciences and Primary Care (M.F.B., C.H.v.G.), and Department of Radiology (R.M.P., W.B.V.), University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.ORCID 0000-0002-9798-6843
Carla H van GilsFrom the Image Sciences Institute (H.W., B.H.M.v.d.V., E.V., K.G.A.G.), Julius Center for Health Sciences and Primary Care (M.F.B., C.H.v.G.), and Department of Radiology (R.M.P., W.B.V.), University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.ORCID 0000-0003-0817-7567
Kenneth G A GilhuijsFrom the Image Sciences Institute (H.W., B.H.M.v.d.V., E.V., K.G.A.G.), Julius Center for Health Sciences and Primary Care (M.F.B., C.H.v.G.), and Department of Radiology (R.M.P., W.B.V.), University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.ORCID 0000-0003-2087-8649

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Automated identification of quantitative breast parenchymal enhancement features on dynamic contrast-enhanced (DCE) MRI scans could provide added value in assessment of breast cancer risk in women with extremely dense breasts. Purpose To automatically identify quantitative properties of the breast parenchyma on baseline DCE MRI scans and assess their association with breast cancer occurrence in women with extremely dense breasts. Materials and Methods This study represents a secondary analysis of the Dense Tissue and Early Breast Neoplasm Screening trial. MRI was performed in eight hospitals between December 2011 and January 2016. After segmentation of fibroglandular tissue, quantitative features (including volumetric density, volumetric morphology, and enhancement characteristics) of the parenchyma were extracted from baseline MRI scans. Principal component analysis was used to identify parenchymal measures with the greatest variance. Multivariable Cox proportional hazards regression was applied to assess the association between breast cancer occurrence and quantitative parenchymal features, followed by stratification of significant features into tertiles. Results A total of 4553 women (mean age, 55.7 years ± 6 [SD]) with extremely dense breasts were included; of these women, 122 (3%) were diagnosed with breast cancer. Five principal components representing 96% of the variance were identified, and the component explaining the greatest independent variance (42%) consisted of MRI features relating to volume of enhancing parenchyma. Multivariable analysis showed that volume of enhancing parenchyma was associated with breast cancer occurrence (hazard ratio [HR], 1.09; 95% CI: 1.01, 1.18;

Indexed as

Breast NeoplasmsBreastBreast DensityFemaleHumansMagnetic Resonance ImagingMammographyMiddle Aged

Identifiers

PMID37552061

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.