Evidence map›Paper›PMID 37551930›Full record

ArticleLab on a chip2023

Programmable magnetic robot (ProMagBot) for automated nucleic acid extraction at the point of need.

Anthony J Politza, Tianyi Liu, Weihua Guan

Open access · greenAbstract read
In one paragraph

Article in Lab on a chip, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
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  8. Sample-to-answer salivary miRNA testing: New frontiers in point-of-care diagnostic technologies.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anthony J PolitzaDepartment of Biomedical Engineering, Pennsylvania State University, University Park 16802, USA. wzg111@psu.edu.
Tianyi LiuDepartment of Electrical Engineering, Pennsylvania State University, University Park 16802, USA.
Weihua GuanDepartment of Biomedical Engineering, Pennsylvania State University, University Park 16802, USA. wzg111@psu.edu.ORCID 0000-0002-8435-9672
Pennsylvania State University · US

Funding

Severity Predictors Integrating salivary Transcriptomics and proteomics with Multi neural network Intelligence in SARS-CoV2 infection in Children (SPITS MISC)R33HD105610 · NICHD · CENTRAL MICHIGAN UNIVERSITY · PI HICKS, STEVEN DANIEL, SETHURAMAN, USHA · 2023 to 2023
$1.4M
Home Fingerprick Blood-Based HIV Self-Test For Quantitative Monitoring Of Viral ReboundR33AI147419 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI GUAN, WEIHUA · 2023 to 2024
$1.3M
Home Fingerprick Blood-Based HIV Self-Test For Quantitative Monitoring Of Viral ReboundR61AI147419 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI GUAN, WEIHUA · 2020 to 2022
$1.0M
NIAID NIH HHS R33 AI147419NIAID NIH HHS R61 AI147419
6 · The paper itself

Abstract

Upstream sample preparation remains the bottleneck for point-of-need nucleic acid testing due to its complexity and time-consuming nature. Sample preparation involves extracting, purifying, and concentrating nucleic acids from various matrices. These processes are critical for ensuring the accuracy and sensitivity of downstream nucleic acid amplification and detection. However, current sample preparation methods are often laboratory-based, requiring specialized equipment, trained personnel, and several hours of processing time. As a result, sample preparation often limits the speed, portability, and cost-effectiveness of point-of-need nucleic acid testing. A universal, field-deployable sample preparation device is highly desirable for this critical need and unmet challenge. Here we reported a handheld, battery-powered, reconfigurable, and field-deployable nucleic acid sample preparation device. A programmable electromagnetic actuator was developed to drive a magnetic robot (ProMagBot) in

Indexed as

Nucleic AcidsRoboticsMagnetic PhenomenaMagneticsNucleic Acid Amplification TechniquesNucleic Acids

Identifiers

PMID37551930
PMCPMC11218199
OpenAlexW4385560471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.