ArticleJournal of diabetes investigation2023
Association between hemoglobin glycation index and non-alcoholic fatty liver disease in the patients with type 2 diabetes mellitus.
Article in Journal of diabetes investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Sex-specific in the nonlinear associations of hemoglobin glycation index and all-cause mortality in the general US adult population: results from NHANES 1999-2018.Nutrition & metabolism · 2026Article
- Hemoglobin glycation index and mortality risk in severe community-acquired pneumonia: a retrospective study.Journal of thoracic disease · 2026Article
- Association between hemoglobin glycation index and mortality in critically ill patients with chronic obstructive pulmonary disease: a retrospective cohort study.European journal of medical research · 2026Article
- Association of Hemoglobin Glycation Index With All-Cause Mortality, Cardiac Mortality, and Cardiovascular Mortality in the General Population: A Retrospective Cohort Study of NHANES Data.Reviews in cardiovascular medicine · 2025Article
- Hemoglobin glycation index among adults with type 1 diabetes: Association with double diabetes features.World journal of diabetes · 2025Article
- What is new in metabolic dysfunction-associated steatotic liver disease?Journal of diabetes investigation · 2025Review
- Association between the haemoglobin glycation index and 30-day and 365-day mortality in patients with heart failure admitted to the intensive care unit.Diabetology & metabolic syndrome · 2025Article
- Cardiac metabolic index as a predictor of new-onset diabetes in non-alcoholic fatty liver disease patients: a longitudinal cohort analysis.BMC endocrine disorders · 2025Article
- Glycated haemoglobin index is a new predictor for all-cause mortality and cardiovascular mortality in the adults.Scientific reports · 2024Article
- Risk analysis of the association between different hemoglobin glycation index and poor prognosis in critical patients with coronary heart disease-A study based on the MIMIC-IV database.Cardiovascular diabetology · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
AIMS/
introductionThe hemoglobin glycation index (HGI) represent the disparity between actual glycated hemoglobin measurements and predicted HbA1c. It serves as a proxy for the degree of non-enzymatic glycation of hemoglobin, which has been found to be positively correlated with diabetic comorbidities. In this study, we investigated the relationship between HGI and non-alcoholic fatty liver disease (NAFLD), along with other relevant biological markers in patients with diabetes. MATERIALS AND
methodsThis cross-sectional study consisted of 3,191 adults diagnosed with type 2 diabetes mellitus. We calculated the predicted glycated hemoglobin levels based on fasting blood glucose levels. Multivariate binary logistic regression analysis was conducted to examine the correlation between the HGI and NAFLD. Hepatic steatosis was diagnosed using ultrasonography.
resultsAmong all participants, 1,784 (55.91%) were diagnosed with NAFLD. Participants with confirmed NAFLD showed elevated body mass index, diastolic blood pressure, liver enzyme, total cholesterol, triglyceride, low-density lipoprotein and uric acid levels compared with those without NAFLD. In the unadjusted model, participants in the last tertile of HGI were 1.40-fold more likely to develop NAFLD than those in the first tertile (95% confidence interval 1.18-1.66; P < 0.001). In the fully adjusted model, those in the last tertile of HGI had a 39% increased risk of liver steatosis compared with confidence interval in the first tertile of HGI (95% confidence interval 1.12-1.74; P < 0.001).
conclusionsA higher HGI suggests an elevated risk of developing NAFLD in patients with type 2 diabetes.
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