Evidence map›Paper›PMID 37551589›Full record

ArticleStroke2023

Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke.

Lieza G Exalto, Nick A Weaver, Hugo J Kuijf, Hugo P Aben, Hee-Joon Bae, Jonathan G Best, Régis Bordet, Christopher P L H Chen, Ruben S van der Giessen, Olivier Godefroy and 26 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  17. Research progress in the relationship between gut microbiota metabolite trimethylamine N-oxide and ischemic stroke.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors at 19 institutions in 8 countries.

Lieza G ExaltoDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, the Netherlands (L.G.E., N.A.W., I.M.C.H.W., L.J.K., M.J.E.v.Z., J.M.B., G.J.B.).ORCID 0000-0003-1475-536X
Nick A WeaverDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, the Netherlands (L.G.E., N.A.W., I.M.C.H.W., L.J.K., M.J.E.v.Z., J.M.B., G.J.B.).ORCID 0000-0001-8425-8436
Hugo J KuijfImage Sciences Institute, University Medical Center Utrecht, the Netherlands (H.J.K.).ORCID 0000-0001-6997-9059
Hugo P AbenDepartment of Neurology, Elisabeth Tweesteden Hospital, Tilburg, the Netherlands (H.P.A., P.L.M.d.K.).ORCID 0000-0003-3032-8843
Hee-Joon BaeDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea (H.-J.B., J.K., B.J.K.).ORCID 0000-0003-0051-1997
Jonathan G BestStroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom (J.G.B., D.J.W.).
Régis BordetUniversité Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, F-Lille, France (R.B.).ORCID 0000-0003-3916-6422
Christopher P L H ChenDepartment of Pharmacology, National University of Singapore (C.P.L.H.C., S.H., X.X.).ORCID 0000-0002-1047-9225
Ruben S van der GiessenDepartment of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands (R.S.v.d.G., P.J.K.).ORCID 0000-0001-8726-9587
Olivier GodefroyDepartment of Neurology, Amiens University hospital, Laboratory of Functional Neurosciences, Jules Verne Picardy University, France (O.G., M.R.).ORCID 0000-0001-6789-6620
Bibek GyanwaliMemory, Aging and Cognition Center, National University Health System, Singapore, Singapore (C.P.L.H.C., B.G., S.H., X.X.).
Olivia K L HamiltonNeuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, United Kingdom (O.K.L.H., M.d.C.V.-H., J.M.W.).ORCID 0000-0002-5874-0058
Saima HilalDepartment of Pharmacology, National University of Singapore (C.P.L.H.C., S.H., X.X.).ORCID 0000-0001-5434-5635
Irene M C Huenges WajerDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, the Netherlands (L.G.E., N.A.W., I.M.C.H.W., L.J.K., M.J.E.v.Z., J.M.B., G.J.B.).
Jonguk KimDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea (H.-J.B., J.K., B.J.K.).ORCID 0000-0002-3026-9532
L Jaap KappelleDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, the Netherlands (L.G.E., N.A.W., I.M.C.H.W., L.J.K., M.J.E.v.Z., J.M.B., G.J.B.).ORCID 0000-0001-8665-6630
Beom Joon KimDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea (H.-J.B., J.K., B.J.K.).ORCID 0000-0002-2719-3012
Sebastian KöhlerDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, the Netherlands (S.K., F.R.J.V.).ORCID 0000-0002-2398-0609
Paul L M de KortDepartment of Neurology, Elisabeth Tweesteden Hospital, Tilburg, the Netherlands (H.P.A., P.L.M.d.K.).ORCID 0000-0002-6031-2255
Peter J KoudstaalDepartment of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands (R.S.v.d.G., P.J.K.).ORCID 0000-0003-4998-9609
Jae-Sung LimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (J.-S.L.).ORCID 0000-0001-6157-2908
Stephen D J MakinCentre For Rural Health, Institute of Applied Health Sciences, University of Aberdeen, United Kingdom (S.D.J.M.).ORCID 0000-0001-8701-9043
Vincent C T MokDivision of Neurology, Department of Medicine and Therapeutics (V.C.T.M.), The Chinese University of Hong Kong.
Robert J van OostenbruggeDepartment of Neurology, Maastricht University Medical Center, the Netherlands (R.J.v.O., J.S.).ORCID 0000-0003-1032-9099
Martine RousselDepartment of Neurology, Amiens University hospital, Laboratory of Functional Neurosciences, Jules Verne Picardy University, France (O.G., M.R.).
Julie StaalsDepartment of Neurology, Maastricht University Medical Center, the Netherlands (R.J.v.O., J.S.).ORCID 0000-0002-9502-6937
Maria Del C Valdés-HernándezNeuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, United Kingdom (O.K.L.H., M.d.C.V.-H., J.M.W.).ORCID 0000-0003-2771-6546
Narayanaswamy VenketasubramanianRaffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore (N.V.).ORCID 0000-0003-3593-6362
Frans R J VerheyDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, the Netherlands (S.K., F.R.J.V.).
Joanna M WardlawNeuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, United Kingdom (O.K.L.H., M.d.C.V.-H., J.M.W.).ORCID 0000-0002-9812-6642
David J WerringStroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom (J.G.B., D.J.W.).ORCID 0000-0003-2074-1861
Xin XuDepartment of Pharmacology, National University of Singapore (C.P.L.H.C., S.H., X.X.).ORCID 0000-0002-4639-6480
Martine J E van ZandvoortDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, the Netherlands (L.G.E., N.A.W., I.M.C.H.W., L.J.K., M.J.E.v.Z., J.M.B., G.J.B.).ORCID 0000-0003-3992-2750
J Matthijs Biesbroek *Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, the Netherlands (L.G.E., N.A.W., I.M.C.H.W., L.J.K., M.J.E.v.Z., J.M.B., G.J.B.).ORCID 0000-0001-7017-2148
Francesca M Chappell *Social and Public Health Sciences Unit (F.M.C.), University of Glasgow, United Kingdom.ORCID 0000-0002-7742-1757
Geert Jan BiesselsDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, the Netherlands (L.G.E., N.A.W., I.M.C.H.W., L.J.K., M.J.E.v.Z., J.M.B., G.J.B.).ORCID 0000-0001-6862-2496
MACOM (United States) · USNational University of Singapore · SGSeoul National University Bundang Hospital · KRWellcome Centre for Integrative Neuroimaging · GBElisabeth-TweeSteden Ziekenhuis · NLErasmus MC · NLMaastricht University · NLMaastricht University Medical Centre · NLUniversité de Picardie Jules Verne · FRAsan Medical Center · KRChinese University of Hong Kong · HKInserm · FRInstitute of Ophthalmology · MXMRC/CSO Social and Public Health Sciences Unit · GBNational University Health System · SGRaffles Institution · SGTwitter (United States) · USUniversity of Aberdeen · GBUtrecht University · NL

Funding

Chief Scientist Office SPHSU17Medical Research Council MC_UU_00022/2Medical Research Council MR/J006971/1
6 · The paper itself

Abstract

backgroundPoststroke cognitive impairment (PSCI) occurs in about half of stroke survivors. Cumulative evidence indicates that functional outcomes of stroke are worse in women than men. Yet it is unknown whether the occurrence and characteristics of PSCI differ between men and women.

methodsIndividual patient data from 9 cohorts of patients with ischemic stroke were harmonized and pooled through the Meta-VCI-Map consortium (n=2343, 38% women). We included patients with visible symptomatic infarcts on computed tomography/magnetic resonance imaging and cognitive assessment within 15 months after stroke. PSCI was defined as impairment in ≥1 cognitive domains on neuropsychological assessment. Logistic regression analyses were performed to compare men to women, adjusted for study cohort, to obtain odds ratios for PSCI and individual cognitive domains. We also explored sensitivity and specificity of cognitive screening tools for detecting PSCI, according to sex (Mini-Mental State Examination, 4 cohorts, n=1814; Montreal Cognitive Assessment, 3 cohorts, n=278).

resultsPSCI was found in 51% of both women and men. Men had a lower risk of impairment of attention and executive functioning (men: odds ratio, 0.76 [95% CI, 0.61-0.96]), and language (men: odds ratio, 0.67 [95% CI, 0.45-0.85]), but a higher risk of verbal memory impairment (men: odds ratio, 1.43 [95% CI, 1.17-1.75]). The sensitivity of Mini-Mental State Examination (<25) for PSCI was higher for women (0.53) than for men (0.27;

conclusionsSex was not associated with PSCI occurrence but affected domains differed between men and women. The latter may explain why sensitivity of the Mini-Mental State Examination for detecting PSCI was higher in women with a lower specificity compared with men. These sex differences need to be considered when screening for and diagnosing PSCI in clinical practice.

Indexed as

Cognitive DysfunctionIschemic StrokeStrokeExecutive FunctionFemaleHumansMaleSex Characteristicscognitionischemic strokemensurvivorswomen

Identifiers

PMID37551589
PMCPMC10453354
OpenAlexW4385660103

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.