SynthesisCurrent neuropharmacology2024
Hair Cortisol Research in Posttraumatic Stress Disorder - 10 Years of Insights and Open Questions. A Systematic Review.
Synthesis in Current neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early biological and psychosocial factors associated with PTSD onset and persistence in youth.European journal of psychotraumatology · 2024Pooled it
- The role of long-term hair steroids as diagnostic and intervention-related biomarkers in a multimorbid inpatient sample with posttraumatic stress disorder.European journal of psychotraumatology · 2025Trial
- Psychological and biological long-term consequences of trauma in the Yazidi population displaced from Shingal after the genocide.European journal of psychotraumatology · 2026Article
- Time-dependent association between prenatal hair glucocorticoid levels and child behavior problems.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- From lifetime stressor exposure to daily stress experience: Associations with hair cortisol.Comprehensive psychoneuroendocrinology · 2026Article
- Eye movement desensitisation and reprocessing as a potential treatment for substance use disorders: study protocol.European journal of psychotraumatology · 2025Article
- Understanding postmigration stress in forcibly displaced people in Austria: study protocol of a 14-day ambulatory assessment study.European journal of psychotraumatology · 2025Article
- Emotion dysregulation modulates the relation between emotional intensity and biological stress dysregulation among community women experiencing intimate partner violence.Psychoneuroendocrinology · 2025Article
- Sex differences in associations between hair glucocorticoids and internalizing symptoms in adolescents.Comprehensive psychoneuroendocrinology · 2025Article
- Experimental PTSD Models in Zebrafish: A Systematic Review of Behavioral, Neurochemical, and Molecular Outcomes.Biology · 2025Review
- The relationship between hair cortisol and trauma sequelae in motor vehicle crash survivors: the role of childhood trauma experiences.Translational psychiatry · 2025Article
- Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- The association between pre-pregnancy and first-trimester hair cortisol and preterm birth: a causal inference model.European journal of epidemiology · 2024Article
- Age and Hair Cortisol Levels as Predictors of SARS-CoV-2 Infection.International journal of environmental research and public health · 2024Article
- Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundCortisol is one of the most extensively studied biomarkers in the context of trauma/posttraumatic stress disorder (PTSD). For more than a decade, hair cortisol concentrations (HCC) have been measured in this context, leading to a two-staged dysregulation model. Specifically, an elevated secretion during/immediately after trauma exposure eventually reverts to hyposecretion with increasing time since trauma exposure has been postulated.
objectiveThe aim of our systematic review was to re-evaluate the two-staged secretion model with regard to the accumulated diagnostic, prognostic, and intervention-related evidence of HCC in lifetime trauma exposure and PTSD. Further, we provide an overview of open questions, particularly with respect to reporting standards and quality criteria.
methodA systematic literature search yielded 5,046 records, of which 31 studies were included.
resultsFor recent/ongoing (traumatic) stress, the predictions of cortisol hypersecretion could be largely confirmed. However, for the assumed hyposecretion temporally more distal to trauma exposure, the results are more ambiguous. As most studies did not report holistic overviews of trauma history and confounding influences, this may largely be attributable to methodological limitations. Data on the prognostic and intervention-related benefits of HCC remain sparse.
conclusionOver the last decade, important insights could be gained about long-term cortisol secretion patterns following lifetime trauma exposure and PTSD. This systematic review integrates these insights into an updated secretion model for trauma/PTSD. We conclude with recommendations for improving HCC research in the context of trauma/PTSD in order to answer the remaining open questions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.