Evidence map›Paper›PMID 37550819›Full record

ArticleBrain tumor research and treatment2023

Comparing the Expression of Canonical and Non-Canonical Inflammasomes Across Glioma Grades: Evaluating Their Potential as an Aggressiveness Marker.

Yu Jin Kim, Wooseok Choi, JeongMin Sim, Ju Won Ahn, JeongMan Park, Dongkil Kim, Ju-Yeon Jeong, Ji Min Lee, Kyunggi Cho, Jong-Seok Moon and 3 more

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In one paragraph

Article in Brain tumor research and treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yu Jin Kim *Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.ORCID https://orcid.org/0009-0002-2021-376X
Wooseok Choi *Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine, Seongnam, Korea.ORCID https://orcid.org/0009-0002-5869-6787
JeongMin SimDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.ORCID https://orcid.org/0009-0009-0447-3706
Ju Won AhnDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.ORCID https://orcid.org/0000-0002-2552-5861
JeongMan ParkDepartment of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine, Seongnam, Korea.ORCID https://orcid.org/0000-0003-2849-4594
Dongkil KimDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.ORCID https://orcid.org/0009-0004-9951-8076
Ju-Yeon JeongCHA Future Medicine Research Institute, Bundang CHA Medical Center, Seongnam, Korea.
Ji Min LeeCHA Future Medicine Research Institute, Bundang CHA Medical Center, Seongnam, Korea.
Kyunggi ChoDepartment of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine, Seongnam, Korea.
Jong-Seok MoonSoonchunhyang Institution of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan, Korea.
Ju Hyung MoonDepartment of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8925-5821
Kyoung Su SungDepartment of Neurosurgery, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea. sungks1465@gmail.com.ORCID https://orcid.org/0000-0003-3289-0143
Jaejoon LimDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.ORCID https://orcid.org/0000-0001-8299-8078

Funding

Korean Society for Neuro OncologyMinistry of Science, Technology and Information, Republic of Korea 2021R1F1A105780111Ministry of Science, Technology and Information, Republic of Korea 2022R1F1A1067203
6 · The paper itself

Abstract

backgroundInflammasomes are key in the initiation of inflammatory responses and serve to defend the organism. However, when the immune system is imbalanced, these complexes contribute to tumor progression. The purpose of this study was to investigate the effect of non-canonical inflammasomes on glioma malignancy.

methodsWe performed bioinformatics analysis to confirm the expression of canonical and non-canonical inflammasome-related molecules according to the degree of malignancy through immunohistochemical examination of glioma tissues obtained with patient consent from our institution.

resultsBioinformatics analysis confirmed that the expression levels of non-canonical inflammasome-related molecules were significantly higher in tumor tissues than in normal tissues, and they also increased according to malignancy, which adversely affected the survival rate. Furthermore, in gliomas, positive correlations were found between N-form gasdermin-D, a key molecule associated with the non-canonical inflammasome, and other related molecules, including NLRP3, caspase-1, caspase-4, and caspase-5. These results were verified by immunohistochemical examination of glioma tissues, and the expression levels of these molecules also increased significantly with increasing grade. In addition, the features of pyroptosis were confirmed.

conclusionThis study identified the potential of non-canonical inflammasomes as aggressiveness markers for gliomas and presented a perspective for improving glioma treatment.

Indexed as

BiomarkersDisease progressionGliomaInflammasomesPyroptosis

Identifiers

PMID37550819
PMCPMC10409615

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