SynthesisArthritis research & therapy2023
Association between periodontitis and temporomandibular joint disorders.
Synthesis in Arthritis research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Multivariate GWAS reveals shared genetic basis of common oral diseases.Frontiers in genetics · 2026Article
- Dental publications on the treatment of temporomandibular disorders: A bibliometric analysis.F1000Research · 2026Review
- Causal relationship between obstructive sleep apnea and diabetic nephropathy: bidirectional and multivariable Mendelian randomization study.Renal failure · 2025Article
- Uncovering the gut microbiota's role in temporomandibular joint disorders: A bidirectional Mendelian randomization study.Medicine · 2025Article
- Article
- A Bidirectional Mendelian Randomization Study of Tea-Drinking Habits and Risk of Elevated Serum Uric Acid Levels.International journal of rheumatic diseases · 2025Article
- Causal associations between sexually transmitted infections, depression, and self-harm: a mendelian randomization and cross-sectional study.BMC infectious diseases · 2024Article
- Assessing Causal Relationships Between Periodontitis and Non-alcoholic Fatty Liver Disease: A Two-Sample Bidirectional Mendelian Randomisation Study.Oral health & preventive dentistry · 2024Article
- Unraveling the causality between chronic obstructive pulmonary disease and its common comorbidities using bidirectional Mendelian randomization.European journal of medical research · 2024Article
- Correction: Association between periodontitis and temporomandibular joint disorders.Arthritis research & therapy · 2023Article
- A Cross sectional Study to Assess the Prevalence of Periodontitis and its Association with Temporomandibular Joint Disorders among Pre and Postmenopausal Women.Journal of mid-life healthArticle
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontitis (PD) may affect temporomandibular joint disorders (TMD) and TMD may influence PD in previous observational studies. Nevertheless, these studies were prone to confounders and reverse causation, leading to incorrect conclusions about causality and direction of association. This research investigates the associations between PD and TMD employing bidirectional two-sample Mendelian randomization (MR) analysis.
methodsSingle-nucleotide polymorphisms (SNPs) related to PD (p < 5 × 10
resultsPD did not appear to causally affect TMD. Additionally, the reverse MR analysis did not reveal a significant causal effect of TMD on PD. The results of other MR methods were similar to those of the IVW method. Sensitivity analyses addressed no potential pleiotropy in MR estimations. Results from the meta-analysis were consistent with the above-mentioned consequences.
conclusionThis research does not support a causal relationship between PD and TMD. PD does not appear to worsen TMD directly, and vice versa.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.