Evidence map›Paper›PMID 37550703›Full record

ArticleTrials2023

Effects of remote ischemic conditioning on conditioned pain modulation and cardiac autonomic modulation in women with knee osteoarthritis: placebo-controlled randomized clinical trial protocol.

Taíse Mendes Biral, Allysiê Priscilla de Souza Cavina, Eduardo Pizzo Junior, Carlos Alberto Toledo Teixeira Filho, Franciele Marques Vanderlei

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05059652 (Effects of Ischemic Preconditioning on Conditioned Pain Modulation and Heart Rate Variability in Women With Knee Osteoarthritis), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05059652 nacompletednot on this map

Effects of Ischemic Preconditioning on Conditioned Pain Modulation and Heart Rate Variability in Women With Knee Osteoarthritis: Placebo-Controlled Randomized Clinical Trial

TypeinterventionalSponsorPaulista UniversityRan2023 to 2024Enrolled44ConditionsIschemic PreconditioningArmsIschemic Preconditioning
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Taíse Mendes BiralPostgraduate Program in Movement Sciences, São Paulo State University (Unesp), School of Technology and Sciences, Presidente Prudente, SP, Brazil. taisemendes_@hotmail.com.ORCID http://orcid.org/0000-0003-0717-2609
Allysiê Priscilla de Souza CavinaPostgraduate Program in Physiotherapy, São Paulo State University (Unesp), School of Technology and Sciences, Presidente Prudente, SP, Brazil.
Eduardo Pizzo JuniorPostgraduate Program in Movement Sciences, São Paulo State University (Unesp), School of Technology and Sciences, Presidente Prudente, SP, Brazil.
Carlos Alberto Toledo Teixeira FilhoPostgraduate Program in Movement Sciences, São Paulo State University (Unesp), School of Technology and Sciences, Presidente Prudente, SP, Brazil.
Franciele Marques VanderleiPostgraduate Program in Movement Sciences, São Paulo State University (Unesp), School of Technology and Sciences, Presidente Prudente, SP, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade São Judas Tadeu · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

backgroundIt is estimated that over 240 million people worldwide have osteoarthritis, which is a major contributor to chronic pain and central changes in pain processing, including endogenous pain modulation. The autonomic nervous system plays a crucial role in the pain regulatory process. One of the main mechanisms of remote ischemic conditioning is neuronal signaling from the preconditioned extremity to the heart. This study aims to analyze the acute effect of remote ischemic conditioning on local pain, conditioned pain modulation, and cardiac autonomic control in women with knee osteoarthritis and to see if there is a correlation between them.

methodsWomen more than 50 years with knee osteoarthritis diagnosed according to the American College of Rheumatology criteria in the postmenopausal period will be considered eligible. The study will have blind randomization, be placebo-controlled, and be balanced in a 1:1 ratio. The total of 44 participants will be divided into two groups (22 participants per group): (i) remote ischemic conditioning and (ii) placebo remote ischemic conditioning. Protocol consisting of four cycles of total ischemia, followed immediately by four cycles of 5 min of vascular reperfusion, totaling 40 min. The primary outcomes in the protocol are conditioned pain modulation, which has the pressure pain threshold (kgf/cm DISCUSSION: It is believed that the results of this study will present a new perspective on the interaction between the pain processing system and the cardiovascular system; they will provide the professional and the patient with a greater guarantee of cardiovascular safety in the use of the intervention; it will provide knowledge about acute responses and this will allow future chronic intervention strategies that aim to be used in the clinical environment, inserted in the multimodal approach, for the treatment of osteoarthritis of the knee.

trial registrationClinicalTrials.gov NCT05059652. Registered on 30 August 2021. Last update on 28 March 2023.

Indexed as

Chronic PainOsteoarthritis, KneeAutonomic Nervous SystemFemaleHumansIschemiaRandomized Controlled Trials as TopicTreatment OutcomeAutonomic nervous systemChronic painConditioned pain modulationHeart rate variabilityIschemic preconditioningOsteoarthritisRandomized controlled trialTherapeutic occlusion

Identifiers

PMID37550703
PMCPMC10405415
OpenAlexW4385635734

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.