Evidence map›Paper›PMID 37550593›Full record

ArticleEuropean journal of nutrition2023

A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice.

Maria O'Keeffe, Åge Oterhals, Hrafn Weishaupt, Sabine Leh, Arve Ulvik, Per Magne Ueland, Alfred Halstensen, Hans-Peter Marti, Oddrun Anita Gudbrandsen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Maria O'KeeffeDietary Protein Research Group, Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, 5021, Bergen, Norway.ORCID http://orcid.org/0000-0002-1056-7794
Åge OterhalsNofima, Bergen, Norway.ORCID http://orcid.org/0000-0002-5378-4131
Hrafn WeishauptDepartment of Pathology, Haukeland University Hospital, Bergen, Norway.ORCID http://orcid.org/0000-0002-0764-2941
Sabine LehDepartment of Pathology, Haukeland University Hospital, Bergen, Norway.
Arve UlvikBevital AS, Bergen, Norway.
Per Magne UelandBevital AS, Bergen, Norway.ORCID http://orcid.org/0000-0002-1903-0571
Alfred HalstensenDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Hans-Peter MartiDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-6331-5902
Oddrun Anita GudbrandsenDietary Protein Research Group, Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, 5021, Bergen, Norway. oddrun.gudbrandsen@k1.uib.no.ORCID http://orcid.org/0000-0001-5268-692X
Haukeland University Hospital · NOBevital (Norway) · NOUniversity of Bergen · NONofima · NO

Funding

Norges Forskningsråd 280498
6 · The paper itself

Abstract

purposeThe obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish proteins would attenuate or delay the development of glomerular hypertrophy (glomerulomegaly), mesangial sclerosis and albuminuria in obese BTBR ob/ob mice.

methodsObese BTBR.CgLep

resultsThe Cod-BB diet attenuated the development of mesangial sclerosis (P 0.040) without affecting the development of glomerular hypertrophy and albuminuria. The urine concentration of cystatin C (relative to creatinine) was lower in mice fed the Cod-BB diet (P 0.0044).

conclusionA diet containing cod backbone protein powder attenuated the development of mesangial sclerosis and tubular dysfunction in obese BTBR ob/ob mice, but did not prevent the development of glomerular hypertrophy and albuminuria in these mice.

Indexed as

AlbuminuriaDiabetic NephropathiesAnimalsCaseinsDietHumansHypertrophyMaleMiceMice, ObeseNephrotic SyndromeObesitySclerosisCaseinsAtlantic codFish proteinsGlomerulomegalyObesity

Identifiers

PMID37550593
PMCPMC10611847
OpenAlexW4385628761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.