Evidence map›Paper›PMID 37550395›Full record

ArticleScientific reports2023

Effects of repeated sleep deprivation on brain pericytes in mice.

Yan Wu, Pengfei Li, Narayan Bhat, Hongkuan Fan, Meng Liu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Chemogenetic modulation of CNS pericytes: Impact on pericyte CaMolecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yan WuDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA.
Pengfei LiPathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.
Narayan BhatNeuroscience, Medical University of South Carolina, Charleston, SC, 29425, USA.
Hongkuan FanPathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.
Meng LiuDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA. liumen@musc.edu.
Medical University of South Carolina · US

Funding

The Role of Pericytes in Brain Hypoperfusion in Alzheimer's Disease DevelopmentR01AG081807 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Hongkuan Fan · 2023 to 2026
$2.5M
Gene Transfer for Cataplexy of NarcolepsyR01NS096151 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LIU, MENG · 2016 to 2020
$2.2M
Sleep, Pericytes, and Alzheimer's DiseaseRF1AG077570 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LIU, MENG · 2022 to 2022
$2.0M
The Role of Pericytes in the Vascular Dysfunction of SepsisR35GM149203 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Hongkuan Fan · 2023 to 2026
$1.8M
The Role of Pericytes in the Vascular Dysfunction of SepsisR01GM130653 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FAN, HONGKUAN · 2018 to 2021
$1.3M
Sleep, Pericytes, and Alzheimer's DiseaseR01AG077570 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Meng Liu · 2025 to 2026
$1.2M
Cellular Mechanism underlying emotional problems of Alzheimer's diseaseR21AG067445 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LIU, MENG · 2020 to 2021
$411k
NIA NIH HHS R01 AG077570NIA NIH HHS R01 AG081807NIA NIH HHS R21 AG067445NIA NIH HHS RF1 AG077570NIGMS NIH HHS R01 GM130653NIGMS NIH HHS R35 GM149203NINDS NIH HHS R01 NS096151
6 · The paper itself

Abstract

The damaging effects of sleep deprivation (SD) on brain parenchyma have been extensively studied. However, the specific influence of SD on brain pericytes, a primary component of the blood-brain barrier (BBB) and the neurovascular unit (NVU), is still unclear. The present study examined how acute or repeated SD impairs brain pericytes by measuring the cerebrospinal fluid (CSF) levels of soluble platelet-derived growth factor receptor beta (sPDGFRβ) and quantifying pericyte density in the cortex, hippocampus, and subcortical area of the PDGFRβ-P2A-CreER

Indexed as

BrainPericytesSleep DeprivationAnimalsBrain InjuriesCaspase 3MiceMice, TransgenicReceptor, Platelet-Derived Growth Factor betaCasp3 protein, mouseCaspase 3Receptor, Platelet-Derived Growth Factor beta

Identifiers

PMID37550395
PMCPMC10406921
OpenAlexW4385631327

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.