ArticleNature communications2023
Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Spaces and sequences in the hippocampus: a homological perspective.Journal of computational neuroscience · 2026Article
- Preconfigured neuronal firing sequences in human brain organoids.Nature neuroscience · 2026Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Generative emergence of non-local representations in the hippocampus.Nature communications · 2025Article
- Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep.Nature communications · 2025Article
- Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory.iScience · 2025Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.eLife · 2024Article
- Repetition dynamically and rapidly increases cortical, but not hippocampal, offline reactivation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Nested compressed co-representations of multiple sequential experiences during sleep.Nature neuroscience · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.bioRxiv : the preprint server for biology · 2024Article
- Article
- The generative grammar of the brain: a critique of internally generated representations.Nature reviews. Neuroscience · 2024Review
- Article
- Accounting for multiscale processing in adaptive real-world decision-making via the hippocampus.Frontiers in neuroscience · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Sequences of spiking activity have been heavily implicated as potential substrates of memory formation and retrieval across many species. A parallel line of recent evidence also asserts that sequential activity may arise from and be constrained by pre-existing network structure. Here we reconcile these two lines of research in the human brain by measuring single unit spiking sequences in the temporal lobe cortex as participants perform an episodic memory task. We find the presence of an average backbone spiking sequence identified during pre-task rest that is stable over time and different cognitive states. We further demonstrate that these backbone sequences are composed of both rigid and flexible sequence elements, and that flexible elements within these sequences serve to promote memory specificity when forming and retrieving new memories. These results support the hypothesis that pre-existing network dynamics serve as a scaffold for ongoing neural activity in the human cortex.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.