ArticleComparative medicine2023
Seasonal Variation of Laboratory Animals as a Consideration for Research Reproducibility.
Article in Comparative medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Seasonal variations in the polysomnographic sleep/wake cycle and activity/rest pattern in the dromedary camel (Camelus dromedarius).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Experimental robustness and reproducibility of the murine cecal ligation and puncture sepsis model.Intensive care medicine experimental · 2026Article
- Antibodies to mannose-binding lectin and factor XI Inhibit Shiga toxin-induced kidney injury additively in a murine model.Pediatric research · 2026Article
- Acute anomalous high-temperature exposure impacts on mouse ovaries.Journal of assisted reproduction and genetics · 2026Article
- Environmental Exposure to the Common Trunk of Mammalian Appeasing Pheromone Modulates Social Behavior and Reduces Fight Wounds in Male Mice.Animals : an open access journal from MDPI · 2025Article
- Article
- Rapid wing size evolution in African fig flies (Zaprionus indianus) following temperate colonization.Evolution; international journal of organic evolution · 2025Article
- AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice.Communications biology · 2025Article
- Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice.Biology of sex differences · 2025Article
- Cross-Sex Hormone Therapy Is Associated With Loss of Circadian Rhythm in the Male Rat.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Extrinsic Environmental Variables: The Umwelt of Research Animals and the Implications for the 3Rs and Study Reproducibility.Journal of the American Association for Laboratory Animal Science : JAALAS · 2024Article
- Increased incidence of weight-loss-associated humane endpoints in rats administered buprenorphine slow-release LAB formulation following traumatic brain injury: a retrospective study.Frontiers in neurology · 2024Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laboratory rodents are generally maintained under standardized conditions in order to control the effects of extrinsic factors on research. However, despite attempts to standardize conditions, variability can nonetheless confound efforts directed toward research reproducibility. Here we explore some of the existing literature on the potential impact of seasonal variability as an extrinsic factor that can potentially impact research results. We discuss the influence of seasonal changes in association with an internal clock mechanism that might account for such variation, noting that the mechanisms and interactions of seasonal and internal time-keeping remain largely undetermined. Finally, we speculate that seasonal changes experienced by personnel who handle animals may influence the animals in ways that result in physiologic and behavioral changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.