Evidence map›Paper›PMID 37550056›Full record

ArticleComparative medicine2023

Evaluation of Uveitis Induced in Rats by a Type I Collagen Peptide as a Model for Childhood Arthritis-associated Uveitis.

Stephanie C Osinchuk, Bruce H Grahn, Tracy D Wilson, Brooke N Thompson, David A Hart, Kim D Harrison, David Ml Cooper, Arash Panahifar, Alan M Rosenberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comparative medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Stephanie C OsinchukDepartment of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Bruce H GrahnDepartment of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Tracy D WilsonDepartment of Pediatrics, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Brooke N ThompsonCanadian Centre for Health and Safety in Agriculture, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
David A HartDepartment of Surgery, University of Calgary, Calgary, Alberta, Canada.
Kim D HarrisonDepartment of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan; Saskatoon, Saskatchewan, Canada.
David Ml CooperDepartment of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan; Saskatoon, Saskatchewan, Canada.
Arash PanahifarCanadian Light Source, Saskatoon, Saskatchewan, Canada; Department of Medical Imaging, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Alan M RosenbergDepartment of Pediatrics, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Corresponding author. alan. rosenberg@usask. ca.
University of Saskatchewan · CACanadian Light Source (Canada) · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic asymptomatic and acute symptomatic anterior uveitis are forms of ocular inflammation associated with juvenile idiopathic arthritis (JIA) Chronic JIA-associated uveitis is characterized by young age of onset, female predilection, oligoarthritis, and antinuclear antibody (ANA) positivity. Acute JIA-associated uveitis predominantly affects older male juveniles who also develop enthesitis. A type I collagen-derived peptide (melanin-associated antigen [MAA]) induces anterior uveitis in rodents. In this study, we evaluated MAA-induced uveitis in rats as a potential model for JIA-uveitis. We characterized MAA-induced uveitis by assessing its relationship to age and sex; tracking the occurrence of arthritis, enthesitis, and ANA positivity; and measuring vitreous fluid inflammatory biomarkers. Juvenile and adult and male and female Lewis rats (

Indexed as

Arthritis, JuvenileUveitisUveitis, AnteriorAnimalsBiomarkersChildCollagen Type IFemaleHumansInflammationMaleRatsRats, Inbred LewBiomarkersCollagen Type I

Identifiers

PMID37550056
PMCPMC10702287
OpenAlexW4385619380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.