Evidence map›Paper›PMID 37549967›Full record

ArticlePhysiological reports2023

Effects of photobiomodulation and caffeine treatment on acute kidney injury in a hypoxic ischemic neonatal rat model.

A M Groves, C J Johnston, G Beutner, J E Dahlstrom, M Koina, M O'Reilly, B Marples, G Porter, P D Brophy, A L Kent

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

A M GrovesDepartment of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.ORCID https://orcid.org/0000-0003-1810-5532
C J JohnstonDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
G BeutnerDepartment of Pediatrics, Division of Cardiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
J E DahlstromDepartment of Anatomical Pathology, Canberra Hospital, Woden, Australian Capital Territory, Australia.
M KoinaDepartment of Anatomical Pathology, Canberra Hospital, Woden, Australian Capital Territory, Australia.
M O'ReillyDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
B MarplesDepartment of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
G PorterDepartment of Pediatrics, Division of Cardiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
P D BrophyDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
A L KentDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
Effect of Neonatal Hyperoxia on Alveolar Development and InfectionR01HL091968 · NHLBI · UNIVERSITY OF ROCHESTER · PI O'REILLY, MICHAEL A · 2009 to 2021
$5.4M
Cyclophilin D Regulates Neonatal Cardiac Bioenergetics and FunctionR01HL144776 · NHLBI · UNIVERSITY OF ROCHESTER · PI PORTER, GEORGE A · 2019 to 2022
$2.0M
NHLBI NIH HHS R01HL091068NHLBI NIH HHS R01 HL091968NHLBI NIH HHS R01 HL144776NHLBI NIH HHS R01HL144776NIEHS NIH HHS P30 ES001247
6 · The paper itself

Abstract

Hypoxic ischemic encephalopathy (HIE) occurs in 2-5/1000 births, with acute kidney injury (AKI) occurring in 40%. AKI increases morbidity and mortality. Caffeine, an adenosine receptor antagonist, and photobiomodulation (PBM), working on cytochrome c oxidase, are potential treatments for AKI. To examine effects of caffeine and PBM on AKI in rats, Day 7 pups underwent a HIE intervention (Modified Rice-Vannucci model) replicating pathology observed in humans. Caffeine was administered for 3 days and/or PBM for 5 days following HIE. Weights and urine for biomarkers (NGAL, albumin, KIM-1, osteopontin) were collected prior to HIE, daily post intervention and at sacrifice. Both treatments reduced kidney injury seen on electron microscopy, but not when combined. HIE elevated urinary NGAL and albumin on Days 1-3 post-HIE, before returning to control levels. This elevation was significantly reduced by PBM or caffeine. KIM-1 was significantly elevated for 7 days post-HIE and was reduced by both treatments. Osteopontin was not altered by HIE or the treatments. Treatments, individually but not in combination, improved HIE-induced reductions in the enzymatic activity of mitochondrial complexes II-III. PBM and caffeine also improved weight gain. PBM and caffeine reduces AKI diagnosed by urinary biomarkers and confirmed by EM findings.

Indexed as

Acute Kidney InjuryHypoxia-Ischemia, BrainAlbuminsAnimalsAnimals, NewbornBiomarkersCaffeineHumansIschemiaLipocalin-2RatsAlbuminsBiomarkersCaffeineLipocalin-2

Identifiers

PMID37549967
PMCPMC10406568

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.