Evidence map›Paper›PMID 37549882›Full record

Trial reportClinical and experimental pharmacology & physiology2023

Intraoperative hemodynamics and risk of cardiac surgery-associated acute kidney injury: An observation study and a feasibility clinical trial.

Khin M Noe, Andrea Don, Andrew D Cochrane, Michael Z L Zhu, Jennifer P Ngo, Julian A Smith, Amanda G Thrift, Johnny Vogiatjis, Andrew Martin, Rinaldo Bellomo and 2 more

Open access · hybridAbstract readObservational StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and experimental pharmacology & physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Khin M NoeCardiovascular Disease Program, Department of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Andrea DonCardiovascular Disease Program, Department of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Andrew D CochraneDepartment of Surgery, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
Michael Z L ZhuCardiovascular Disease Program, Department of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Jennifer P NgoCardiovascular Disease Program, Department of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0001-9980-9640
Julian A SmithDepartment of Surgery, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
Amanda G ThriftDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
Johnny VogiatjisCardiovascular Disease Program, Department of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Andrew MartinCardiovascular Disease Program, Department of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Rinaldo BellomoDepartment of Critical Care, University of Melbourne, Melbourne, Victoria, Australia.
James McMillanPerfusion Services Pty Ltd, Melbourne, Victoria, Australia.
Roger G EvansCardiovascular Disease Program, Department of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-9241-0757
Discovery Institute · USMonash Health · AUThe University of Melbourne · AUServices Australia · AU

Funding

National Health and Medical Research Council of AustraliaNational Heart Foundation of Australia
6 · The paper itself

Abstract

Targeting greater pump flow and mean arterial pressure (MAP) during cardiopulmonary bypass (CPB) could potentially alleviate renal hypoxia and reduce the risk of postoperative acute kidney injury (AKI). Therefore, in an observational study of 93 patients undergoing on-pump cardiac surgery, we tested whether intraoperative hemodynamic management differed between patients who did and did not develop AKI. Then, in 20 patients, we assessed the feasibility of a larger-scale trial in which patients would be randomized to greater than normal target pump flow and MAP, or usual care, during CPB. In the observational cohort, MAP during hypothermic CPB averaged 68.8 ± 8.0 mmHg (mean ± SD) in the 36 patients who developed AKI and 68.9 ± 6.3 mmHg in the 57 patients who did not (p = 0.98). Pump flow averaged 2.4 ± 0.2 L/min/m

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresFeasibility StudiesHemodynamicsHumansPostoperative Complicationsarterial pressurecardiopulmonary bypassclinical perfusionpump flowsystemic oxygen delivery

Identifiers

PMID37549882
PMCPMC10947000
OpenAlexW4385621684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.