Evidence map›Paper›PMID 37549453›Full record

ArticleDevelopmental cognitive neuroscience2023

Gestational and postnatal age associations for striatal tissue iron deposition in early infancy.

Laura Cabral, Finnegan J Calabro, Jerod Rasmussen, Will Foran, Lucille A Moore, Alice Graham, Thomas G O'Connor, Pathik D Wadhwa, Sonja Entringer, Damien Fair and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cognitive neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Laura CabralDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: cabrall@upmc.edu.
Finnegan J CalabroDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Jerod RasmussenDevelopment, Health and Disease Research Program, University of California, Irvine, CA 92697, USA; Department of Pediatrics, University of California, Irvine, CA 92697, USA.
Will ForanDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Lucille A MooreMasonic Institute for the Developing Brain, University of Minnesota, USA.
Alice GrahamDepartment of Psychiatry, Oregon Health & Science University, Portland, OR 97239, USA.
Thomas G O'ConnorDepartments of Psychiatry, Neuroscience, and Obstetrics and Gynecology, University of Rochester, Rochester, NY 14642, USA.
Pathik D WadhwaDevelopment, Health, and Disease Research Program, Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine, CA, USA; Department of Pediatrics, University of California, Irvine, School of Medicine, Orange, CA, USA; Departments of Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Orange, CA, USA.
Sonja EntringerDevelopment, Health, and Disease Research Program, Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine, CA, USA; Department of Pediatrics, University of California, Irvine, School of Medicine, Orange, CA, USA; Institute of Medical Psychology, Charité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Damien FairMasonic Institute for the Developing Brain, University of Minnesota, USA.
Claudia BussDevelopment, Health, and Disease Research Program, Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine, CA, USA; Department of Pediatrics, University of California, Irvine, School of Medicine, Orange, CA, USA; Institute of Medical Psychology, Charité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Ashok PanigrahyDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Beatriz LunaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

CLINICAL RESEARCH TRAINING IN CHILD PSYCHIATRYT32MH018951 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TINA R GOLDSTEIN · 1990 to 2026
$9.7M
Pre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUG3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI BARRETT, EMILY S, MILLER, RICHARD KERMIT · 2016 to 2024
$7.0M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
FETAL PROGRAMMING OF THE NEWBORN AND INFANT HUMAN BRAINR01MH091351 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, WADHWA, PATHIK D · 2011 to 2015
$3.3M
Neurobiological and neurocognitive consequences of diverse microbiome functional trajectoriesR01MH125103 · NIMH · UNIVERSITY OF ROCHESTER · PI STEVEN R. GILL, Thomas G O'Connor · 2022 to 2026
$3.2M
Fetal Programming of Human Newborn Energy Homeostasis Brain NetworksR00HD100593 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI RASMUSSEN, JEROD MICHAEL · 2023 to 2025
$744k
NICHD NIH HHS R00 HD100593NICHD NIH HHS R01 HD060628NIH HHS UG3 OD023349NIMH NIH HHS R01 MH091351NIMH NIH HHS R01 MH125103NIMH NIH HHS T32 MH018951
6 · The paper itself

Abstract

Striatal development is crucial for later motor, cognitive, and reward behavior, but age-related change in striatal physiology during the neonatal period remains understudied. An MRI-based measure of tissue iron deposition, T2*, is a non-invasive way to probe striatal physiology neonatally, linked to dopaminergic processing and cognition in children and adults. Striatal subregions have distinct functions that may come online at different time periods in early life. To identify if there are critical periods before or after birth, we measured if striatal iron accrued with gestational age at birth [range= 34.57-41.85 weeks] or postnatal age at scan [range= 5-64 days], using MRI to probe the T2* signal in N = 83 neonates in three striatal subregions. We found iron increased with postnatal age in the pallidum and putamen but not the caudate. No significant relationship between iron and gestational age was observed. Using a subset of infants scanned at preschool age (N = 26), we show distributions of iron shift between time points. In infants, the pallidum had the least iron of the three regions but had the most by preschool age. Together, this provides evidence of distinct change for striatal subregions, a possible differentiation between motor and cognitive systems, identifying a mechanism that may impact future trajectories.

Indexed as

Corpus StriatumPutamenAdultChildChild, PreschoolDopamineHumansInfantInfant, NewbornIronMagnetic Resonance ImagingDopamineIronDevelopment of t2* signal in infancyEarly brain trajectoriesStriatumSubcortical developmentTissue iron

Identifiers

PMID37549453
PMCPMC10423888

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.