Evidence map›Paper›PMID 37549296›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Collaborative privacy-preserving analysis of oncological data using multiparty homomorphic encryption.

Ravit Geva, Alexander Gusev, Yuriy Polyakov, Lior Liram, Oded Rosolio, Andreea Alexandru, Nicholas Genise, Marcelo Blatt, Zohar Duchin, Barliz Waissengrin and 11 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ravit Geva *Tel Aviv Sorasky Medical Center, Tel Aviv 64239, Israel.ORCID 0000-0002-5380-4948
Alexander Gusev *Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
Yuriy Polyakov *Duality Technologies, Inc., Hoboken, NJ 07103.ORCID 0000-0002-5566-3763
Lior Liram *Duality Technologies, Inc., Hoboken, NJ 07103.
Oded Rosolio *Duality Technologies, Inc., Hoboken, NJ 07103.
Andreea Alexandru *Duality Technologies, Inc., Hoboken, NJ 07103.
Nicholas Genise *Duality Technologies, Inc., Hoboken, NJ 07103.
Marcelo Blatt *Duality Technologies, Inc., Hoboken, NJ 07103.
Zohar Duchin *Duality Technologies, Inc., Hoboken, NJ 07103.
Barliz Waissengrin *Tel Aviv Sorasky Medical Center, Tel Aviv 64239, Israel.
Dan Mirelman *Tel Aviv Sorasky Medical Center, Tel Aviv 64239, Israel.
Felix Bukstein *Tel Aviv Sorasky Medical Center, Tel Aviv 64239, Israel.
Deborah T Blumenthal *Tel Aviv Sorasky Medical Center, Tel Aviv 64239, Israel.
Ido Wolf *Tel Aviv Sorasky Medical Center, Tel Aviv 64239, Israel.
Sharon Pelles-Avraham *Tel Aviv Sorasky Medical Center, Tel Aviv 64239, Israel.
Tali Schaffer *Tel Aviv Sorasky Medical Center, Tel Aviv 64239, Israel.
Lee A Lavi *Tel Aviv Sorasky Medical Center, Tel Aviv 64239, Israel.
Daniele Micciancio *Duality Technologies, Inc., Hoboken, NJ 07103.
Vinod Vaikuntanathan *Duality Technologies, Inc., Hoboken, NJ 07103.
Ahmad Al Badawi *Duality Technologies, Inc., Hoboken, NJ 07103.
Shafi Goldwasser *Duality Technologies, Inc., Hoboken, NJ 07103.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real-world healthcare data sharing is instrumental in constructing broader-based and larger clinical datasets that may improve clinical decision-making research and outcomes. Stakeholders are frequently reluctant to share their data without guaranteed patient privacy, proper protection of their datasets, and control over the usage of their data. Fully homomorphic encryption (FHE) is a cryptographic capability that can address these issues by enabling computation on encrypted data without intermediate decryptions, so the analytics results are obtained without revealing the raw data. This work presents a toolset for collaborative privacy-preserving analysis of oncological data using multiparty FHE. Our toolset supports survival analysis, logistic regression training, and several common descriptive statistics. We demonstrate using oncological datasets that the toolset achieves high accuracy and practical performance, which scales well to larger datasets. As part of this work, we propose a cryptographic protocol for interactive bootstrapping in multiparty FHE, which is of independent interest. The toolset we develop is general-purpose and can be applied to other collaborative medical and healthcare application domains.

Indexed as

Computer SecurityPrivacyClinical Decision-MakingHumansLogistic Modelsmultiparty fully homomorphic encryptiononcologyprivacy-enhancing technologiesprivacy-preserving data collaboration

Identifiers

PMID37549296
PMCPMC10437415

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.