Evidence map›Paper›PMID 37549252›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.

Tanshi Mehrotra, Dipasri Konar, Agila Kumari Pragasam, Shakti Kumar, Pradipta Jana, Prabhakar Babele, Deepjyoti Paul, Ayushi Purohit, Subhash Tanwar, Susmita Bakshi and 20 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

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  10. Unusual case ofFrontiers in cellular and infection microbiology · 2026
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  20. Characterization of OXA232-Producing Carbapenem-ResistantPolish journal of microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 7 institutions in 1 country.

Tanshi Mehrotra *Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Dipasri Konar *Division of Diagnostic Laboratory, Jan Swasthya Sahyog, Ganiyari, Bilaspur 495112, India.
Agila Kumari Pragasam *Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Shakti KumarInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Pradipta JanaInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Prabhakar BabeleInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Deepjyoti PaulInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Ayushi PurohitInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Subhash TanwarMultidisciplinary Clinical and Translational Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Susmita BakshiInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Santanu DasInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Jyoti VermaInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Daizee TalukdarInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Lekshmi NarendrakumarInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Akanksha KothidarInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Sonali Porey KarmakarInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Susmita ChaudhuriMultidisciplinary Clinical and Translational Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Sujoy PalDepartment of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.
Kajal JainDepartment of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.
Chittur V SrikanthLaboratory of Gut Infection and Inflammation Biology, Regional Centre for Biotechnology, Faridabad 121001, India.
M Jeeva SankarDepartment of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India.
Krishnamohan AtmakuriInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Ramesh AgarwalDepartment of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India.
Rajni GaindDepartment of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029, India.
Mamatha BallalDepartment of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576104, India.
Nagamani KammiliDepartment of Microbiology, Pathogen Biology Division, Gandhi Medical College and Hospital, Secunderabad 500003, India.
Rupak K BhadraInfectious Diseases and Immunology Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700 032, India.
Thandavarayan RamamurthyInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
G Balakrish NairInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Bhabatosh DasInfection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.ORCID 0000-0002-2447-5380
Translational Health Science and Technology Institute · INAll India Institute of Medical Sciences · INGandhi Medical College & Hospital · INIndian Institute of Chemical Biology · INManipal Academy of Higher Education · INRegional Centre for Biotechnology · INVardhman Mahavir Medical College & Safdarjung Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbes evolve rapidly by modifying their genomes through mutations or through the horizontal acquisition of mobile genetic elements (MGEs) linked with fitness traits such as antimicrobial resistance (AMR), virulence, and metabolic functions. We conducted a multicentric study in India and collected different clinical samples for decoding the genome sequences of bacterial pathogens associated with sepsis, urinary tract infections, and respiratory infections to understand the functional potency associated with AMR and its dynamics. Genomic analysis identified several acquired AMR genes (ARGs) that have a pathogen-specific signature. We observed that

Indexed as

Anti-Bacterial AgentsEscherichia colibeta-LactamasesDrug Resistance, BacterialDrug Resistance, Multiple, BacterialKlebsiella pneumoniaeMicrobial Sensitivity TestsProteomicsAnti-Bacterial Agentsbeta-Lactamasesantimicrobial resistanceantimicrobialsgenomicsGram-negative pathogensproteomics

Identifiers

PMID37549252
PMCPMC10434301
OpenAlexW4385618078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.