Evidence map›Paper›PMID 37548868›Full record

SynthesisNeuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater2024

Anti-N-methyl-D-aspartate receptor encephalitis in adults: a systematic review and analysis.

Yam R Giri, Allison Parrill, Sreedevi Damodar, Joshua Fogel, Nisrin Ayed, Muhammad Syed, Ijendu Korie, Sivaranjani Ayyanar, Christopher Typhair, Seema Hashmi and 1 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yam R GiriDepartment of Psychiatry and Behavioral Sciences, Nassau University Medical Center, Hempstead Turnpike, 2201, East Meadow, NY, USA. yamrajgiri@gmail.com.
Allison ParrillLake Erie College of Osteopathic Medicine, 1858 W Grandview Blvd, Erie, PA, USA.
Sreedevi DamodarCollege of Medicine, Department of Psychiatry, University of Central Florida, Gainesville, FL, USA.
Joshua FogelDepartment of Business Management, Brooklyn College, Brooklyn, NY, USA.
Nisrin AyedAscension Maccomb-Oakland Hospital, Warren, MI, USA.
Muhammad SyedAscension Maccomb-Oakland Hospital, Warren, MI, USA.
Ijendu KorieHenry Mayo Newhall Hospital, Valencia, CA, USA.
Sivaranjani AyyanarDepartment of Psychiatry and Behavioral Sciences, Nassau University Medical Center, Hempstead Turnpike, 2201, East Meadow, NY, USA.
Christopher TyphairRoger Williams Medical Center, Providence, RI, USA.
Seema HashmiDepartment of Psychiatry and Behavioral Sciences, Nassau University Medical Center, Hempstead Turnpike, 2201, East Meadow, NY, USA.
Bom B GiriXuzhou Medical University, Xuzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo analyze predictors of treatment outcome for anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in adults.

methodsWe performed a comprehensive literature search of PubMed, PsycInfo, and OVID. We included 424 patients from case reports and case series. Demographics, anti-NMDAR antibodies, prodromal and presenting symptoms, diagnostic workup, and treatment variables were recorded. Inferential analyses were performed in the subset (n = 299) of those with known treatment outcomes. Multivariate multinomial logistic regression analysis for treatment outcome compared full recovery versus partial recovery and full recovery versus death.

resultsTreatment outcomes consisted of 34.67% full recovery (n = 147), 30.90% partial recovery (n = 131), 4.95% death (n = 21), and 29.48% unknown (n = 125). Speech/language abnormality and abnormal electroencephalogram (EEG) were each significantly associated with a higher relative risk for a full recovery. Treatment with intravenous immunoglobulin and plasmapheresis were each significantly associated with a higher relative risk for partial recovery. The analysis comparing death to full recovery found that catatonia was significantly associated with a lower relative risk for death. Increased age, orofacial dyskinesia, and no tumor removal were each significantly associated with a higher relative risk for death.

conclusionIncreased age, orofacial dyskinesia, and no tumor removal were associated with a higher relative risk for death in anti-NMDAR encephalitis in adults. Clinicians should monitor and appropriately treat anti-NMDAR encephalitis with these findings to minimize the risk of death.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisPlasmapheresisAdultElectroencephalographyHumansImmunoglobulins, IntravenousTreatment OutcomeImmunoglobulins, IntravenousAnti-NMDAR encephalitisAnti-N-methyl-D-aspartate receptor encephalitidesAutoimmune encephalitisEncephalitides, anti-N-methyl-D-aspartate receptorNonparaneoplastic anti-NMDAR encephalitis

Identifiers

PMID37548868

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.