Evidence map›Paper›PMID 37548860›Full record

ArticleJournal of cardiovascular translational research2024

Early and Accurate Detection of Radiation-induced Heart Damage by Cardiodynamicsgram.

Yuanyuan Tao, Qinghua Sun, Yuchun Wei, Chunmiao Liang, Shanshan Tang, Jiali Li, Jinli Pei, Yang Li, Cong Wang, Shuanghu Yuan

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yuanyuan TaoDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, 250117, Shandong, China.
Qinghua SunSchool of Control Science and Engineering, Shandong University, Jinan, China.
Yuchun WeiDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, 250117, Shandong, China.
Chunmiao LiangSchool of Control Science and Engineering, Shandong University, Jinan, China.
Shanshan TangElectrocardiogram Room, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Jiali LiSchool of Control Science and Engineering, Shandong University, Jinan, China.
Jinli PeiShandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Yang LiShandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Cong WangSchool of Control Science and Engineering, Shandong University, Jinan, China. wangcong@sdu.edu.cn.
Shuanghu YuanDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, 250117, Shandong, China. yuanshuanghu@sina.com.ORCID 0000-0002-8327-2524
Shandong Tumor Hospital · CNShandong University · CN

Funding

the Bethune Charitable Foundation flzh202116the Jinan Clinical Medicine Science and Technology Innovation Plan 202019060the Major Basic Program of Shandong Provincial Natural Science Foundation ZR2020ZD40the Natural Science Foundation of China 82203218the Natural Science Foundation of China NSFC81872475the Natural Science Foundation of China NSFC82073345the Natural Science Foundation of Shandong Province ZR2021QH008
6 · The paper itself

Abstract

Cardiodynamicsgram (CDG) has emerged recently as a noninvasive spatiotemporal electrocardiographic method for subtle cardiac dynamics information analysis within electrocardiogram (ECG). This study explored the feasibility of CDG for detecting radiation-induced heart damage (RIHD) in a rat model. A single radiation dose of 40 Gy was delivered to the cardiac apex of female Wistar rats. First, CDG was generated through dynamic modeling of ECG signals using the deterministic learning algorithm. Furthermore, CDG indexes were calculated using the wavelet transform and entropy. In this model, CDG entropy indexes decreased significantly after radiotherapy. The shape of CDG changed significantly after radiotherapy (irregular shape) compared with controls (regular shape). Macrophage and fibrosis in myocardium of rats increased significantly after radiotherapy. CDG changes after radiotherapy were significantly correlated with histopathological changes and occurred significantly earlier than histopathological changes. This study provides an experimental basis for the clinical application of CDG for the early detection of RIHD.

Indexed as

ElectrocardiographyFeasibility StudiesFibrosisPredictive Value of TestsRadiation Injuries, ExperimentalRats, WistarWavelet AnalysisAlgorithmsAnimalsCardiotoxicityDisease Models, AnimalEarly DiagnosisEntropyFemaleHeartHeart RateCardiodynamicsgramRadiation-induced heart damageRadiotherapy

Identifiers

PMID37548860
OpenAlexW4385619940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.