ArticleNeuroradiology2023
Cerebellar and cerebral white matter changes in Parkinson's disease with resting tremor.
Article in Neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- The causal relationship between neuroimaging and Parkinson's disease: A two-sample Mendelian randomization study.Medicine · 2026Article
- Subregional alterations in corpus callosum is associated with different symptoms in early-stage parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Association of motor subtype and tremor type with Parkinson's disease progression: An exploratory longitudinal analysis.Journal of Parkinson's disease · 2025Article
- Comparison of diffusion tensor imaging (DTI) tissue characterization parameters in white matter tracts of patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD).European radiology · 2024Article
- White matter biomarker for predicting de novo Parkinson's disease using tract-based spatial statistics: a machine learning-based model.Quantitative imaging in medicine and surgery · 2024Article
- A more objective PD diagnostic model: integrating texture feature markers of cerebellar gray matter and white matter through machine learning.Frontiers in aging neuroscience · 2024Article
- Functional brain controllability in Parkinson's disease and its association with motor outcomes after deep brain stimulation.Frontiers in neuroscience · 2024Article
- Differential brain iron deposition in Parkinson's disease subtypes: a comparative quantitative susceptibility mapping study of tremor-dominant versus postural instability/gait difficulty phenotypes.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
purposeCerebellum modulates the amplitude of resting tremor in Parkinson's disease (PD) via cerebello-thalamo-cortical (CTC) circuit. Tremor-related white matter alterations have been identified in PD patients by pathological studies, but in vivo evidence is limited; the influence of such cerebellar white matter alterations on tremor-related brain network, including CTC circuit, is also unclear. In this study, we investigated the cerebral and cerebellar white matter alterations in PD patients with resting tremor using diffusion tensor imaging (DTI).
methodsIn this study, 30 PD patients with resting tremor (PDWR), 26 PD patients without resting tremor (PDNR), and 30 healthy controls (HCs) from the Parkinson's Progression Markers Initiative (PPMI) cohort were included. Tract-based spatial statistics (TBSS) and region of interest-based analyses were conducted to determine white matter difference. Correlation analysis between DTI measures and clinical characteristics was also performed.
resultsIn the whole brain, TBSS and region of interest-based analyses identified higher fractional anisotropy (FA) value, lower mean diffusivity (MD) value, and lower radial diffusivity (RD) in multiple fibers. In the cerebellum, TBSS analysis revealed significantly higher FA value, decreased RD value as well as MD value in multiple cerebellar tracts including the inferior cerebellar peduncle (ICP) and middle cerebellar peduncle (MCP) when comparing the PDWR with HC, and higher FA value in the MCP when compared with PDNR.
conclusionWe identified better white matter integrity in the cerebrum and cerebellum in PDWR indicating a potential association between the cerebral and cerebellar white matter and resting tremor in PD.
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