ArticleJournal of veterinary internal medicine
A prospective evaluation of the prevalence of thromboemboli and associated hemostatic dysfunction in dogs with carcinoma or sarcoma.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 8 citations in OpenAlex.
- Carcinoma of Unknown Primary Origin Presenting as Rapidly Progressive Multifocal Skeletal Lesions and Fatal Systemic Thrombosis in a Dog: A Case Report.Veterinary sciences · 2026Article
- Alterations in Erythrocyte and Platelet Characteristics Are Poor Indicators of Metastasis in Dogs with Carcinoma or Sarcoma: A Preliminary Study.Veterinary sciences · 2026Article
- Thromboembolic disease and hemostatic alterations in tumor-bearing dogs - A narrative review.Frontiers in veterinary science · 2026Review
- Biochemical and haemostatic variables associated with metastasis in dogs with carcinoma or sarcoma.The Journal of small animal practice · 2026Article
- Thromboelastographic Assessment of Coagulation Profiles in Dogs with Cardiac Tumors and Their Relationship to Cardiac Function.Animals : an open access journal from MDPI · 2025Article
- Retrospective Study of Clinicopathological Changes and Prediction Model for Canine Vascular Neoplasms.Veterinary sciences · 2024Article
- Prospective Estimation of the Prevalence of Thromboembolism in Dogs With Inflammatory Protein-Losing Enteropathy.Journal of veterinary internal medicineArticle
- A prospective evaluation of the prevalence of thromboemboli and associated hemostatic dysfunction in dogs with carcinoma or sarcoma.Journal of veterinary internal medicineArticle
- Influence of Carcinoma and Sarcoma on Neutrophil Gelatinase-Associated Lipocalin and Symmetric Dimethylarginine Concentrations in Dogs.Journal of veterinary internal medicineArticle
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundKnowledge of the prevalence of thromboemboli and the associated hemostatic status in dogs with carcinoma or sarcoma is unknown and might allow earlier intervention.
objectivesEstimate prevalence of thromboemboli and their association with hemostatic changes in dogs with carcinomas or sarcomas; estimate predictive values of hemostatic variables for thromboembolic disease in tumor-bearing dogs. ANIMALS: Thirty-two dogs with sarcoma, 30 with carcinoma, 20 healthy age-controlled dogs.
methodsProspective cross-sectional study. A hemostasis panel (platelet concentration, thromboelastography, fibrinogen and D-dimer concentration, factor X, VII and antithrombin activity) was performed in all dogs. Tumor-bearing dogs underwent complete post mortem and histopathological evaluation. Comparisons between healthy dogs and tumor-bearing dogs with and without intracavitary hemorrhage; and tumor-bearing dogs with and without microthrombi were analyzed.
resultsThromboembolic disease was identified in 32/62 (52%, 95% CI: 39%-65%) tumor-bearing dogs. Microthrombi were identified in 31/62 (50%, 95% CI: 37%-63%) dogs, 21/31 (68%, 95% CI: 49%-83%) had exclusively intra-tumoral microthrombi, 10/31 (32%, 95% CI: 17%-51%) had distant microthrombi. Macrothrombi were identified in 3 tumor-bearing dogs. Hemostatic changes potentially consistent with overt and non-overt disseminated intravascular coagulation were identified in some tumor-bearing dogs. D-dimer concentrations were significantly higher (P = .02) and platelet concentration significantly lower (P = .03) in tumor-bearing dogs with microthrombi compared to tumor-bearing dogs without microthrombi. D-dimer concentration above 500 ng/mL was 80% sensitive and 41% specific for the prediction of microthrombi presence.
conclusionThe high microthrombi prevalence and concomitant hemostatic dysfunction in dogs with carcinomas or sarcomas has not previously been reported, though the clinical importance is unknown. Increased D-dimer concentration might increase suspicion of microthrombi.
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