Evidence map›Paper›PMID 37548584›Full record

Observational studyEuropean journal of neurology2024

Neuropathies related to hepatitis E virus infection: A prospective, matched case-control study.

Paolo Ripellino, Agustina Maria Lascano, Olivier Scheidegger, Lenka Schilg-Hafer, Bettina Schreiner, Pinelopi Tsouni, Alex Vicino, Anne-Kathrin Peyer, Andrea Monika Humm, Bernhard Friedrich Décard and 14 more

Open access · hybridAbstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Immune triggers preceding neuralgic amyotrophy.European journal of neurology · 2024
    Observational
  4. Review
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 13 institutions in 2 countries.

Paolo RipellinoDepartment of Neurology, Neurocenter of Southern Switzerland EOC, Lugano, Switzerland.ORCID 0000-0002-8662-9656
Agustina Maria LascanoNeurology Division, Department of Clinical Neuroscience, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0001-7572-8811
Olivier ScheideggerDepartment of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Lenka Schilg-HaferDepartment of Neurology, Cantonal Hospital, St. Gallen, Switzerland.
Bettina SchreinerDepartment of Neurology, University and Hospital Zurich, Zurich, Switzerland.
Pinelopi TsouniService de Neurologie, Hôpital du Valais, Sion, Switzerland.
Alex VicinoNerve-Muscle Unit, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-6420-8124
Anne-Kathrin PeyerCantonal Hospital, Lucerne, Switzerland.
Andrea Monika HummDepartment of Medicine, Neurology Unit, HFR Fribourg Cantonal Hospital, Fribourg, Switzerland.
Bernhard Friedrich DécardDepartment of Neurology, University Hospital and University of Basel, Basel, Switzerland.
Enea PianezziLaboratory of Microbiology EOC, Bellinzona, Switzerland.
Giulia ZezzaLaboratory of Microbiology EOC, Bellinzona, Switzerland.
Davide SparasciDepartment of Neurology, Neurocenter of Southern Switzerland EOC, Lugano, Switzerland.ORCID 0000-0002-6190-1633
Thomas HundsbergerDepartment of Neurology, Cantonal Hospital, St. Gallen, Switzerland.
Anelia DietmannDepartment of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.ORCID 0000-0002-8949-0645
Hans JungDepartment of Neurology, University and Hospital Zurich, Zurich, Switzerland.
Thierry KuntzerNerve-Muscle Unit, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Einar Wilder-SmithDepartment of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Gladys Martinetti-LucchiniLaboratory of Microbiology EOC, Bellinzona, Switzerland.
Orlando PetriniUniversity of Applied Sciences and Arts of Southern Switzerland, Bellinzona, Switzerland.ORCID 0000-0002-1234-7832
Stefano FontanaBlood Transfusion Service SRC Southern Switzerland, Lugano, Switzerland.
Peter GowlandInterregional Blood Transfusion SRC, Bern, Switzerland.
Christoph NiederhauserInterregional Blood Transfusion SRC, Bern, Switzerland.
Claudio GobbiDepartment of Neurology, Neurocenter of Southern Switzerland EOC, Lugano, Switzerland.ORCID 0000-0002-7554-0664
University of Bern · CHEnte Ospedaliero Cantonale · CHLaboratory for Biomedical Neurosciences · CHSwiss Red Cross · CHUniversity Hospital of Zurich · CHUniversity of Lausanne · CHUniversity of St.Gallen · CHFribourg Development Agency · CHHôpital du Valais · CHUniversity of Applied Sciences and Arts of Southern Switzerland · CHUniversity of Basel · CHUniversity of Geneva · CHUniversity of Lucerne · CH

Funding

Baasch-Medicus Stiftung of Zurich, GBS/CIDP Initiative SchweizFondation pour le progress en Neurologie of LausanneNeuromuscular Research Association (NERAB) of Basel
6 · The paper itself

Abstract

backgroundAcute hepatitis E virus (HEV) infection has recently emerged as a potential trigger for acute dysimmune neuropathies, but prospective controlled studies are lacking.

aimsTo compare the frequency of concomitant acute HEV infection in patients with neuralgic amyotrophy (NA), Guillain-Barré syndrome (GBS), and Bell's palsy with a matched control population.

methodsSwiss multicenter, prospective, observational, matched case-control study over 3 years (September 2019-October 2022). Neurological cases with NA, GBS, or Bell's palsy were recruited within 1 month of disease onset. Healthy controls were matched for age, sex, geographical location, and timing of blood collection. Diagnostic criteria for acute hepatitis E were reactive serum anti-HEV IgM and IgG assays (ELISA test) and/or HEV RNA detection in serum by real-time polymerase chain reaction (RT-PCR). RT-PCR was performed on sera to confirm IgM positivity.

resultsWe included 180 patients (59 GBS, 51 NA, 70 Bell's palsy cases) and corresponding matched controls (blood donors) with median age 51 years for both groups and equal gender distribution. Six IgM+ cases were detected in the NA, two in the GBS, and none in the Bell's palsy group. Two controls were anti-HEV IgM-positive. At disease onset, most cases with acute HEV infection had increased liver enzymes. A moderate association (p = 0.027, Fisher's exact test; Cramér's V = -0.25) was observed only between acute HEV infection and NA.

conclusionThis prospective observational study suggests an association between concomitant acute HEV infection and NA, but not with GBS or Bell's palsy.

Indexed as

Bell PalsyFacial ParalysisGuillain-Barre SyndromeHepatitis EHepatitis E virusAcute DiseaseCase-Control StudiesHepatitis AntibodiesHumansImmunoglobulin MMiddle AgedProspective StudiesHepatitis AntibodiesImmunoglobulin MBell's palsyGuillain-Barré syndromehepatitis Eneuralgic amyotrophyParsonage-Turner syndrome

Identifiers

PMID37548584
PMCPMC11235744
OpenAlexW4385620527

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.