ReviewJournal of feline medicine and surgery2023
Feline chronic gingivostomatitis current concepts in clinical management.
Review in Journal of feline medicine and surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- 2025 FelineVMA feline oral health and dental care guidelines.Journal of feline medicine and surgery · 2025Guideline
- Feline chronic gingivostomatitis: a thorough systematic review of associated factors.Journal of feline medicine and surgery · 2025Pooled it
- Antiviral effect of poly(styrene 4-sulfonate) (PSSNa) on feline calicivirus oral infections in cats-field study.The veterinary quarterly · 2026Article
- Serum peptidomic profiling identifies systemic JAK-STAT and PI3K-Akt pathway dysregulation in cats with chronic gingivostomatitis.Journal of veterinary internal medicine · 2026Article
- Unilateral partial-mouth extraction achieves complete clinical remission in cats with unilateral caudal feline chronic gingivostomatitis: a case series.BMC veterinary research · 2026Article
- Transcriptomic evidence of CD8⁺ T-cell exhaustion-like phenotype and mitochondrial impairment underlying immune dysregulation in feline chronic gingivostomatitis.Scientific reports · 2026Article
- Combination Therapeutic Effect of Antibacterial and Antiviral Agents on Feline Chronic Gingivostomatitis Nonbounded to Prior Tooth Extraction Confirmed by Physical Signs and Clinical Biomarkers.Veterinary sciences · 2026Article
- Long-term field safety study evaluating allogeneic, uterine-derived mesenchymal stem cells for refractory feline chronic gingivostomatitis.Journal of feline medicine and surgery · 2026Article
- Comparison of simple and rapid collection methods for measuring salivary IL-6 and PGEBrazilian journal of veterinary medicine · 2026Article
- Histopathological Features and Clinical Findings of Feline Chronic Gingivostomatitis (FCGS) in Cats (Veterinary medicine international · 2026Article
- Long-term efficacy of cyclosporine and interferon-ω in feline chronic gingivostomatitis: insights from SDAI scores.BMC veterinary research · 2025Article
- Clinical field study evaluating the safety and efficacy of allogeneic uterine-derived mesenchymal stem cells for refractory feline chronic gingivostomatitis.Journal of feline medicine and surgery · 2025Article
- Assessment of Selected Endothelial Damage Biomarkers in the Determination of Endothelial Damage in Cats With Gingivostomatitis.Veterinary medicine and science · 2025Article
- Efficacy and safety of omega-3-enriched lickable treats as adjunctive therapy for feline chronic gingivostomatitis: A randomized controlled trial.Veterinary world · 2025Article
- Feline Calicivirus Infection: Current Understanding and Implications for Control Strategies.Animals : an open access journal from MDPI · 2025Review
- Case Report: Shift from Aggressive Periodontitis to Feline Chronic Gingivostomatitis Is Linked to Increased Microbial Diversity.Pathogens (Basel, Switzerland) · 2025Article
- Clinical and histopathological investigation of the possible occurrence of tracheobronchial disease in cats with chronic gingivostomatitis.Frontiers in veterinary science · 2025Article
- Co-occurrence of feline chronic gingivostomatitis and oral squamous cell carcinoma in 4 cats (2014-2024).Frontiers in veterinary science · 2025Article
- The prevalence of reasons for tooth extraction in cats.Frontiers in veterinary science · 2025Article
- Post-operative supplementation with vitamin D after mucogingival surgery significantly enhances autophagy and improves life quality following feline chronic gingivostomatitis.International journal of veterinary science and medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
practical relevanceFeline chronic gingivostomatitis (FCGS) is a debilitating disease for cats and a challenge for veterinarians and cat caregivers alike. Recent literature indicates that the disease is immune-mediated in nature and likely associated with a chronic viral infection in patients with higher alpha diversity of their subgingival microbiome. The immune-mediated nature of FCGS includes both local as well as systemic effects, and the transcriptomic analysis of affected patients supports these findings. TREATMENT OPTIONS: Localized therapy in the form of surgical extraction of all, or nearly all, teeth continues to be the mainstay of treatment. For cats that do not respond to surgical management, medical management, in the form of immunosuppressive or immunomodulatory therapy, remains an option. Analgesia is of fundamental importance. Immunomodulation utilizing mesenchymal stromal cell therapy provides an alternative treatment avenue for refractory patients and likely targets the chronic viral infection present in this disease. The potential for treatment stratification and use of novel systemic treatment options may be revealed as the molecular pathways involved in this disease are better described.
aimsThis review outlines current and emerging concepts linking available science pertaining to FCGS and clinical management of the disease. EVIDENCE BASE: The article draws on the best evidence base at this juncture and is also driven by the authors' collective experience of working on the disease for over a decade.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.