ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
Cardiovascular health, infection burden, and incident dementia in the UK Biobank.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Hospitalization with infections and risk of Dementia: a systematic review and meta-analysis.Aging · 2025Pooled it
- Severe infections, domain-specific cognitive vulnerability, and future infection risk in older adults.Brain, behavior, & immunity - health · 2026Article
- The interplay of air pollution with plasma neurodegenerative markers and metabolome for dementia, Parkinson's disease and all-cause mortality risks and transitions: The UK Biobank study.Ecotoxicology and environmental safety · 2026Article
- LifeZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Life's Essential 8, Polygenic Risk for Type 2 Diabetes, and Dementia: Evidence from the UK Biobank.Nutrients · 2026Article
- Life's Essential 8-Defined Cardiovascular Health and Mortality Risk in Cardiovascular-Kidney-Metabolic Health Stages 0-4: A Cohort Study.Journal of epidemiology and global health · 2026Article
- Cardiovascular health assessed by Life's Essential 8 score, genetic risk, colonoscopy status, and risk of colorectal cancer: an analysis of UK Biobank.BMJ open gastroenterology · 2026Article
- Neuroretinal and Photoreceptor Layer Thickness Reduction Associates With Impaired Cardiovascular Health: The UK Biobank Study.Investigative ophthalmology & visual science · 2026Article
- Helicobacter pylori infection, atrophic gastritis, and disabling dementia: the Japan Public Health Center-based Prospective Study.Environmental health and preventive medicine · 2026Article
- Childhood Maltreatment and Cardiovascular Health: Role of Sex and Life's Essential 8 in the U.K. Biobank.JACC. Advances · 2026Article
- Viral infection states, immune control, and adult cognition: evidence across latency, persistence, and post-acute responses.Frontiers in immunology · 2026Review
- Socio-environmental and health-related factors and their association with longitudinal change in brain neuroimaging markers through the plasma metabolome among UK adults: An additive Bayesian network analysis.Brain, behavior, & immunity - health · 2025Article
- Cardiovascular-kidney-metabolic syndrome, systemic inflammation, and incident dementia: evidence from 400,740 UK Biobank participants.Diabetology & metabolic syndrome · 2025Article
- Adherence to life's essential 8 and progression trajectory of cardiometabolic multimorbidity: a prospective cohort study.Nutrition & metabolism · 2025Article
- Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank.Investigative ophthalmology & visual science · 2025Article
- The synergy between life's essential 8 and muscle strength on cardiovascular disease risk.Frontiers in medicine · 2025Article
- Infection burden, periodontal pathogens, and their interactive association with incident all-cause and Alzheimer's disease dementia in a large national survey.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Life's essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study.The international journal of behavioral nutrition and physical activity · 2024Article
- Associations between Life's Essential 8 and post-stroke depression and all-cause mortality among US adults.European journal of medical research · 2024Article
- Hospital-treated prevalent infections, the plasma proteome and incident dementia among UK older adults.iScience · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
introductionAmong older adults, total and hospitalized infection may be associated with incidence of all-cause and Alzheimer's disease (AD) dementias, with variation by cardiovascular health (CVH).
methodsWe used Cox proportional hazards (PH) models to examine the relationships between International Classification of Diseases-10th revision (ICD-10)-specific viral and bacterial infectious agents and incident all-cause and AD dementia among 355,046 UK Biobank participants ≥50 years at baseline. Life's Essential 8 (LE8) index reflected CVH.
resultsIn both sexes, total infection burden (yes vs. no) was associated with all-cause dementia, with significant interactions by LE8 tertiles, whereby this relationship was significant only in the lowest LE8 tertile. Hospital-treated infection burden (yes vs no) was significantly related to all-cause and AD dementia, with no significant interaction with LE8 tertile. Age group patterns were detected. DISCUSSION: AD and all-cause dementia were related to hospital-treated infections, while CVH modified the relationship of total infection burden with all-cause dementia. Highlights Secondary analysis on >355,000 UK Biobank participants ≥50 years at baseline. Alzheimer's disease and all-cause dementia are both related to hospital-treated infection. Cardiovascular health modifies association of infection burden with all-cause dementia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.