ArticleCrystal growth & design2023
Navigating the Complex Solid Form Landscape of the Quercetin Flavonoid Molecule.
Article in Crystal growth & design, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Physicochemical Characterization and Larvicidal Activity of a Rutin-Zn Material againstACS omega · 2026Article
- Whey Protein-Based Micro- and Nanocapsules Loaded with Quercetin: Design and Functional Properties.International journal of molecular sciences · 2026Article
- Crystal structures of fisetin dihydrate and luteolin monohydrate: crystallization from ethanol-water mixtures.Acta crystallographica. Section E, Crystallographic communications · 2026Article
- Dietary Polyphenols (Flavonoids) Derived from Plants for Use in Therapeutic Health: Antioxidant Performance, ROS, Molecular Mechanisms, and Bioavailability Limitations.International journal of molecular sciences · 2026Review
- A Combined Experimental and Modeling Workflow to Tune Surface Properties of Organic Materials via Cocrystallization.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Exploring the Potential Role of Quercetin Dihydrate Against Carbon Tetrachloride Induced Oxidative Stress in Mice: A Randomized Control Trial.Food science & nutrition · 2025Article
- Superior solubility of anhydrous quercetin and polymer physical mixtures compared to amorphous solid dispersions.RSC advances · 2025Article
- Polymorphism in oxyresveratrol studied by 3D ED.ACS omega · 2024Article
- Insight into the Manipulation Mechanism of Polymorphic Transformation by Polymers: A Case of Cimetidine.Pharmaceutical research · 2024Article
- Development of Potential Therapeutic Agents from Black Elderberries (the Fruits ofMolecules (Basel, Switzerland) · 2024Review
- Elucidating the Polymorphism of Xanthone: A Crystallization and Characterization Study.Crystal growth & design · 2024Article
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Authors and funding
10 authors.
Funding
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Abstract
Quercetin, a naturally occurring bioflavonoid substance widely used in the nutraceutical and food industries, exists in various solid forms that can have different physicochemical properties, thus impacting this compound's performance in various applications. In this work, we will clarify the complex solid-form landscape of this molecule. Two elusive isostructural solvates of quercetin were obtained from ethanol and methanol. The obtained crystals were characterized experimentally, but the crystallographic structure could not be solved due to their high instability. Nevertheless, the desolvated structure resulting from a high-temperature treatment (or prolonged storage at ambient conditions) of both these two labile crystals was characterized and solved via powder X-ray diffraction and solid-state nuclear magnetic resonance (SSNMR). This anhydrous crystal structure was compared with another anhydrous quercetin form obtained in our previous work, indicating that, at least, two different anhydrous polymorphs of quercetin exist. Navigating the solid-form landscape of quercetin is essential to ensure accurate control of the functional properties of food, nutraceutical, or pharmaceutical products containing crystal forms of this substance.
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