Evidence map›Paper›PMID 37547765›Full record

ArticleOncology research2023

Isolation and characterization of β-transducin repeat-containing protein ligands screened using a high-throughput screening system.

Xintong Liu, Emiko Sanada, Jiang Li, Xiaomeng Li, Hiroyuki Osada, Nobumoto Watanabe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xintong LiuChemical Resource Development Research Unit, RIKEN CSRS, Wako, Saitama, 351-0198, Japan.
Emiko SanadaChemical Resource Development Research Unit, RIKEN CSRS, Wako, Saitama, 351-0198, Japan.
Jiang LiGuangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510180, China.
Xiaomeng LiKingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 510182, China.
Hiroyuki OsadaChemical Resource Development Research Unit, RIKEN CSRS, Wako, Saitama, 351-0198, Japan.
Nobumoto WatanabeChemical Resource Development Research Unit, RIKEN CSRS, Wako, Saitama, 351-0198, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-transducin repeat-containing protein (β-TrCP) is an F-box protein subunit of the E3 Skp1-Cullin-F box (SCF) type ubiquitin-ligase complex, and provides the substrate specificity for the ligase. To find potent ligands of β-TrCP useful for the proteolysis targeting chimera (PROTAC) system using β-TrCP in the future, we developed a high-throughput screening system for small molecule β-TrCP ligands. We screened the chemical library utilizing the system and obtained several hit compounds. The effects of the hit compounds on

Indexed as

beta-Transducin Repeat-Containing ProteinsSKP Cullin F-Box Protein LigasesCullin ProteinsHigh-Throughput Screening AssaysHumansLigandsbeta-Transducin Repeat-Containing ProteinsCullin ProteinsLigandsSKP Cullin F-Box Protein LigasesChemical biologyF-box proteinUbiquitin

Identifiers

PMID37547765
PMCPMC10398414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.