Evidence map›Paper›PMID 37547674›Full record

ArticleFrontiers in microbiology2023

Design, evaluation, and immune simulation of potentially universal multi-epitope mpox vaccine candidate: focus on DNA vaccine.

Nino Rcheulishvili, Jiawei Mao, Dimitri Papukashvili, Shunping Feng, Cong Liu, Xingyun Wang, Yunjiao He, Peng George Wang

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
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  7. Review
  8. Article
  9. Article
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  11. Current advances and challenges in mpox vaccine development: a global landscape.Therapeutic advances in vaccines and immunotherapy · 2025
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nino Rcheulishvili *Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Jiawei Mao *Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Dimitri PapukashviliDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Shunping FengDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Cong LiuDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Xingyun WangDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Yunjiao HeDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Peng George WangDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monkeypox (mpox) is a zoonotic infectious disease caused by the mpox virus. Mpox symptoms are similar to smallpox with less severity and lower mortality. As yet mpox virus is not characterized by as high transmissibility as some severe acute respiratory syndrome 2 (SARS-CoV-2) variants, still, it is spreading, especially among men who have sex with men (MSM). Thus, taking preventive measures, such as vaccination, is highly recommended. While the smallpox vaccine has demonstrated considerable efficacy against the mpox virus due to the antigenic similarities, the development of a universal anti-mpox vaccine remains a necessary pursuit. Recently, nucleic acid vaccines have garnered special attention owing to their numerous advantages compared to traditional vaccines. Importantly, DNA vaccines have certain advantages over mRNA vaccines. In this study, a potentially universal DNA vaccine candidate against mpox based on conserved epitopes was designed and its efficacy was evaluated

Indexed as

DNA vaccineepidemicsimmunoinformaticsin silicomonkeypoxmpox viruspandemicsuniversal vaccine

Identifiers

PMID37547674
PMCPMC10403236

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.