Evidence map›Paper›PMID 37547534›Full record

ArticleKidney international reports2023

Outcomes in ANCA-Associated Vasculitis in Scotland: Validation of the Renal Risk Score in a Complete National Cohort.

Dominic P McGovern, Jennifer S Lees, Jamie P Traynor, Bruce Mackinnon, Samira Bell, Robert W Hunter, Neeraj Dhaun, Wendy Metcalfe, Dana Kidder, Michelle Lim and 10 more

Abstract read
In one paragraph

Article in Kidney international reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Top ten tips in managing ANCA vasculitis.Clinical kidney journal · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Dominic P McGovernGlasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Jennifer S LeesGlasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Jamie P TraynorGlasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Bruce MackinnonDepartment of Nephrology and Transplantation, John Hunter Hospital, New South Wales, Australia.
Samira BellDivision of Population Health and Genomics, University of Dundee, Dundee, UK.
Robert W HunterCentre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.
Neeraj DhaunCentre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.
Wendy MetcalfeRenal Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.
Dana KidderRenal Unit, Aberdeen Royal Infirmary, Aberdeen, UK.
Michelle LimRenal Unit, Ninewells Hospital and Medical School, Dundee, UK.
Nicola JossRenal Unit, Raigmore Hospital, Inverness, UK.
Michael KellyRenal Unit, Dumfries and Galloway Royal Infirmary, Dumfries, UK.
Alison TaylorRenal Unit, Monklands Hospital, Airdrie, UK.
Zoe CouslandRenal Unit, Monklands Hospital, Airdrie, UK.
Vishal DeyRenal Unit, University Hospital Crosshouse, Kilmarnock, UK.
Kate BuckRenal Unit, Queen Margaret Hospital, Fife Acute Hospitals Trust, Kirkcaldy, Fife, UK.
Silke BrixRenal, Urology and Transplantation Unit, Manchester University Hospitals, Manchester, UK.
Colin C GeddesGlasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Emily P McQuarrieGlasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Kathryn I StevensGlasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) causes autoimmune-mediated inflammation of small blood vessels in multiple organs, including the kidneys. The ability to accurately predict kidney outcomes would enable a more personalized therapeutic approach. Methods: We used our national renal biopsy registry to validate the ability of ANCA Renal Risk Score (ARRS) to predict end-stage kidney disease (ESKD) for individual patients. This score uses histopathological and biochemical data to stratify patients as high, medium, or low risk for developing ESKD. Results: A total of 288 patients were eligible for inclusion in the study (low risk Conclusion: The ARRS better discriminates risk of ESKD in AAV and offers clinicians more prognostic information than the use of standard biochemical and clinical measures alone. This is the first time the ARRS has been validated in a national cohort. The proportion of patients with high-risk scores is lower in our cohort compared to others and should be noted as a limitation of this study.

Indexed as

ANCA-associated vasculitis (AAV)ANCA Renal Risk Score (ARRS)biopsy registryend-stage kidney disease (ESKD)

Identifiers

PMID37547534
PMCPMC10403670

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.