Evidence map›Paper›PMID 37547521›Full record

ArticleKidney international reports2023

Clinicopathologic Spectrum of Lysozyme-Associated Nephropathy.

Satoru Kudose, L Nicholas Cossey, Pietro A Canetta, Miroslav Sekulic, Christine A Vanbeek, Forest B Huls, Isha Gupta, Lihong Bu, Mariam P Alexander, Lynn D Cornell and 6 more

Abstract read
In one paragraph

Article in Kidney international reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Renal tubular lysozyme in tubulointerstitial diseases and renal sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  8. Review
  9. Article
  10. Protein handling in kidney tubules.Nature reviews. Nephrology · 2025
    Review
  11. Clonal monocytosis of renal significance.Kidney international · 2024
    Review
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Satoru KudoseDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
L Nicholas CosseyArkana Laboratories, Little Rock, Arkansas, USA.
Pietro A CanettaDepartment of Medicine, Division of Nephrology, Columbia University Irving Medical Center, New York, New York, USA.
Miroslav SekulicDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Christine A VanbeekAmeriPath, Oklahoma City, Oklahoma, USA.
Forest B HulsDepartment of Pathology, Division of Laboratory Medicine, University of Alabama, Birmingham, Alabama, USA.
Isha GuptaMiddletown Medical, Middletown, New York, USA.
Lihong BuMayo Clinic, Rochester, Minnesota, USA.
Mariam P AlexanderMayo Clinic, Rochester, Minnesota, USA.
Lynn D CornellMayo Clinic, Rochester, Minnesota, USA.
Mary E FidlerMayo Clinic, Rochester, Minnesota, USA.
Glen S MarkowitzDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Christopher P LarsenArkana Laboratories, Little Rock, Arkansas, USA.
Vivette D D'AgatiDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Samih H NasrMayo Clinic, Rochester, Minnesota, USA.
Dominick SantorielloDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Lysozyme-associated nephropathy (LyN), a rare cause of kidney injury in patients with chronic myelomonocytic leukemia (CMML), has not been well described to date. We report the clinicopathologic spectrum of LyN from a multi-institutional series. Method: We identified 37 native kidney biopsies with LyN and retrospectively obtained clinicopathologic data. Results: Thirty-seven patients had a median age of 74 years and included 78% males. Their most common presentation was acute kidney injury (AKI) or AKI on chronic kidney disease (CKD) (66%) with median estimated glomerular filtration rate (eGFR) of 21.7 ml/min per 1.73 m Conclusion: Increased awareness of the full clinicopathologic spectrum of LyN may lead to prompt diagnosis, earlier treatment, and potentially improved outcome of this rare entity.

Indexed as

chronic myelomonocytic leukemiagranulomaskidney biopsylysozymelysozyme induced nephropathyproximal tubulopathy

Identifiers

PMID37547521
PMCPMC10403676

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.