ReviewRSC chemical biology2023
Transition metal ions and neurotransmitters: coordination chemistry and implications for neurodegeneration.
Review in RSC chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed.
- Metallothionein and neurodegenerative diseases.Neural regeneration research · 2026Article
- Cu(I) Is a Game Changer in the Arrest of Cu(Aβ)-Induced ROS Production in the Presence of Competing Zn(II) Ions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Molecular Design Strategies Enabling Activity-Based Sensing and Labeling as a Platform for Probing Enzyme Activity, Redox Regulation, and Transition-Metal Signaling.Bioconjugate chemistry · 2026Review
- Quality Evaluation ofPlants (Basel, Switzerland) · 2025Article
- Catalytically controlled formation of coumarin-based hydrogelator enables colorimetric ferrous ion detection in sol and hydrogel.Communications chemistry · 2025Article
- Oxidative Stress-Mediated Neuroinflammation in the Pathophysiology of Schizophrenia.International journal of molecular sciences · 2025Review
- Characterization of the Binding Modes of CuInternational journal of molecular sciences · 2025Article
- Article
- Layered double hydroxides for regenerative nanomedicine and tissue engineering: recent advances and future perspectives.Journal of nanobiotechnology · 2025Review
- Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition.Chemical science · 2025Review
- From coordination to function: Inorganic insights into metalloproteins and metallopeptides in biosystems.Biophysics and physicobiology · 2025Article
- Deciphering the Impact of Nucleosides and Nucleotides on Copper Ion and Dopamine Coordination Dynamics.International journal of molecular sciences · 2024Article
- Cation-Binding of Glutamate in Aqueous Solution.The journal of physical chemistry. B · 2024Article
- Tannic acid ameliorates the hazards effect of beryllium induced neuro-alterations and oxidative stress in adult male rats.Toxicology research · 2024Article
- A review of proposed mechanisms for neurodegenerative disease.Frontiers in aging neuroscience · 2024Review
- Pleiotropic Potential ofMolecules (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurodegeneration is characterized by a disturbance in neurotransmitter-mediated signaling pathways. Recent studies have highlighted the significant role of transition metal ions, including Cu(i/ii), Zn(ii), and Fe(ii/iii), in neurotransmission, thereby making the coordination chemistry of neurotransmitters a growing field of interest in understanding signal dysfunction. This review outlines the physiological functions of transition metal ions and neurotransmitters, with the metal-binding properties of small molecule-based neurotransmitters and neuropeptides. Additionally, we discuss the structural and conformational changes of neurotransmitters induced by redox-active metal ions, such as Cu(i/ii) and Fe(ii/iii), and briefly describe the outcomes arising from their oxidation, polymerization, and aggregation. These observations have important implications for neurodegeneration and emphasize the need for further research to develop potential therapeutic strategies.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.