Evidence map›Paper›PMID 37547216›Full record

ArticleFrontiers in psychiatry2023

The interaction between the major vault protein rs4788186 polymorphism, alcohol dependence, and depression among male Chinese problem drinkers.

Yuyu Wu, Ke Zhao, Yingjie Chen, Liujun Wu, Feng Qiu, Yuying Yuan, Guanghui Shen, Kexin Wang, Yimin Kang, Yongsheng Jiang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuyu WuZhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou, China.
Ke ZhaoLishui Second Affiliated Hospital of Wenzhou Medical University, Lishui, China.
Yingjie ChenCixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, China.
Liujun WuZhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou, China.
Feng QiuSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Yuying YuanSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Guanghui ShenZhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou, China.
Kexin WangZhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou, China.
Yimin KangKey Laboratory of Psychosomatic Medicine, Inner Mongolia Medical University, Huhhot, China.
Yongsheng JiangThe Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, China.
Wei WangZhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou, China.
Li ChenZhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou, China.
Yanlong LiuZhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou, China.
Xuebo PanSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Fan WangBeijing Hui-Long-Guan Hospital, Peking University, Beijing, China.
Longteng XieThe Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Alcohol use disorder (AUD) is the second most prevalent mental disorder and might be related to depression. Major vault protein (MVP) is a cytoplasmic protein related to vesicle transport. The present study aimed to investigate the interaction between a genetic variant (MVP rs4788186) and depression in adult male Han Chinese with AUD during withdrawal. Methods: All participants ( Results: Hierarchical regression analysis identified an interaction between MVP rs4788186 and alcohol dependence level for depression ( Conclusion: Carriers of the AA homozygote of MVP rs4788186 may be more susceptible to severe alcohol problems and higher levels of depression during withdrawal.

Indexed as

alcohol dependencedepressionG × Emajor vault proteinsingle nucleotide polymorphism

Identifiers

PMID37547216
PMCPMC10402753

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.