Evidence map›Paper›PMID 37547072›Full record

ArticleJACC. Basic to translational science2023

Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report.

Giovanni Peretto, Giacomo De Luca, Andrea Villatore, Chiara Di Resta, Simone Sala, Anna Palmisano, Davide Vignale, Corrado Campochiaro, Davide Lazzeroni, Monica De Gaspari and 9 more

2 registry-linked trialsAbstract read
In one paragraph

Article in JACC. Basic to translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06607471 recruitingnot on this map

Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study.

Typeobservational_patient_registrySponsorScientific Institute San RaffaeleRan2018 to 2035Enrolled15,000ConditionsNon-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM), Restrictive CardiomyopathyArmsSupport treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation, Support treatment, cardiac medical treatment, aetiology-specific treatment
NCT06889662 recruitingnot on this mapstarted 2025, after this paper: background citation

GEAM: Yield of GEnetic Testing in Arrhythmic Myocarditis

TypeobservationalSponsorScientific Institute San RaffaeleRan2025 to 2027Enrolled262ConditionsMyocarditis, Ventricular Arrythmia
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Geographical and Ethnic Heterogeneity in Genetic Dilated Cardiomyopathies.International journal of molecular sciences · 2026
    Pooled it
  2. Impact ofCirculation. Cardiovascular imaging · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
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  8. Observational
  9. Observational
  10. Review
  11. Article
  12. Article
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  15. How to prepare a patient for 18F-fluorodeoxyglucose positron emission tomography imaging to assess myocardial inflammation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024
    Article
  16. Review
  17. Article
  18. Reply: Nonischemic Cardiomyopathy: Just a Diagnosis of What YouJACC. Basic to translational science · 2023
    Article
  19. Nonischemic Cardiomyopathy: Just a Diagnosis of What YouJACC. Basic to translational science · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Giovanni PerettoDepartment of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Giacomo De LucaMyocarditis Disease Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Andrea VillatoreMyocarditis Disease Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Chiara Di RestaSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Simone SalaDepartment of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Anna PalmisanoMyocarditis Disease Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Davide VignaleMyocarditis Disease Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Corrado CampochiaroMyocarditis Disease Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Davide LazzeroniIRCCS Fondazione Don Carlo Gnocchi, Parma, Italy.
Monica De GaspariDepartment of Cardiac Thoracic Vascular Sciences and Public Health, Cardiovascular Pathology, Padua University, Padua, Italy.
Stefania RizzoDepartment of Cardiac Thoracic Vascular Sciences and Public Health, Cardiovascular Pathology, Padua University, Padua, Italy.
Elena BusnardoMyocarditis Disease Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Paola FerroMyocarditis Disease Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Luigi GianolliDepartment of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Cristina BassoDepartment of Cardiac Thoracic Vascular Sciences and Public Health, Cardiovascular Pathology, Padua University, Padua, Italy.
Lorenzo DagnaMyocarditis Disease Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Antonio EspositoMyocarditis Disease Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Sara BenedettiUOC Screening Neonatale e Malattie Metaboliche, ASST Fatebenefratelli Sacco-Ospedale dei Bambini "Vittore Buzzi," Milan, Italy.
Paolo Della BellaDepartment of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The authors present a clinical report focused on the overlap between myocarditis and genetic cardiomyopathies of the dilated and arrhythmogenic spectrum. Our cohort was composed of 25 patients undergoing extensive baseline characterization and prospective reassessment by a dedicated multidisciplinary disease unit during a median follow-up of 69 months. We showed that the use of multimodal imaging allowed both discrimination of specific genotypes and identification of myocardial inflammation proven using endomyocardial biopsy. In addition, we showed that the use of immunomodulatory therapy was beneficial for most patients.

Indexed as

cardiomyopathydesmosomal gene variantsendomyocardial biopsygeneticsimmunosuppressive therapymultimodal imagingmyocardial inflammation

Identifiers

PMID37547072
PMCPMC10401291

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.