ArticleJACC. Basic to translational science2023
Bioprosthetic Valve Deterioration: Accumulation of Circulating Proteins and Macrophages in the Valve Interstitium.
Article in JACC. Basic to translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed.
- Alpha-gal xenoantigens in bioprosthetic valve recipients: clinical implications for bioprosthesis longevity.Journal of cardiothoracic surgery · 2026Review
- Dual itaconate delivery systems modulate macrophage Acod1-Hif-1α-glycolysis axis for immunotherapy of bioprosthetic heart valve calcification.Bioactive materials · 2026Article
- Caldesmon-1-mediated actin dynamics is essential for osteogenic differentiation of aortic valve interstitial cells.Scientific reports · 2026Article
- Bioprosthetic heart valve degeneration: new insights into structural remodeling and calcification.Frontiers in cardiovascular medicine · 2026Review
- Transcatheter Aortic Valve Durability: Focus on Structural Valve Deterioration.Journal of the American Heart Association · 2025Review
- Contemporary Multi-modality Imaging of Prosthetic Aortic Valves.Reviews in cardiovascular medicine · 2025Review
- Structural valve deterioration is primarily caused by cyclic fatigue but not immune rejection.Frontiers in immunology · 2025Article
- Macrophages as key modulators of calcific aortic valve disease.Frontiers in cardiovascular medicine · 2025Review
- A Novel Polymer Film to Develop Heart Valve Prostheses.Polymers · 2024Article
- Development of Subcutaneous SSEA3- or SSEA4-Positive Cell Capture Device.Bioengineering (Basel, Switzerland) · 2024Article
- Carotid Artery Bypass Surgery of In-Body Tissue Architecture-Induced Small-Diameter Biotube in a Goat Model: A Pilot Study.Bioengineering (Basel, Switzerland) · 2024Article
- Low-Grade Inflammation: A Familiar Factor in Cardiovascular Diseases.JACC. Basic to translational science · 2023Article
- Reply: Low-Grade Inflammation: A Familiar Factor in Cardiovascular Diseases.JACC. Basic to translational science · 2023Article
- Evaluation of Bioprosthetic Valve Deterioration: Is Tissue Analysis Sufficient?JACC. Basic to translational science · 2023Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histologic evaluations revealed excessive accumulations of macrophages and absence of fibroblastic interstitial cells in explanted bioprosthetic valves. Comprehensive gene and protein expression analysis and histology unveiled an accumulation of fibrinogen and plasminogen, an activator of infiltrated macrophages, from degenerated valve surfaces in the interstitial spaces. These pathologies were completely reproduced in a goat model replaced with an autologous pericardium-derived aortic valve. Further preclinical animal experiments using goats demonstrated that preventing infiltration of macrophages and circulating proteins by increasing collagen density and leaflet strength is an effective treatment option.
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Registered trials
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