Evidence map›Paper›PMID 37546971›Full record

ArticlebioRxiv : the preprint server for biology2023

3D electronic implants in subretinal space: long-term follow-up in rodents.

Mohajeet Bhuckory, Bing-Yi Wang, Zhijie Charles Chen, Andrew Shin, Davis Pham-Howard, Sarthak Shah, Nicharee Monkongpitukkul, Ludwig Galambos, Theodore Kamins, Keith Mathieson and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Mohajeet BhuckoryHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Bing-Yi WangDepartment of Physics, Stanford University, Stanford, CA, USA.
Zhijie Charles ChenDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Andrew ShinDepartment of Material Science, Stanford University, Stanford, CA, USA.
Davis Pham-HowardHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Sarthak ShahHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Nicharee MonkongpitukkulHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Ludwig GalambosHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Theodore KaminsHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Keith MathiesonDepartment of Physics, Institute of Photonics, University of Strathclyde, Glasgow, Scotland, UK.
Daniel PalankerHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Stanford University · USUniversity of Strathclyde · GB

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Photovoltaic Subretinal Prosthesis with High Pixel DensityR01EY027786 · NEI · STANFORD UNIVERSITY · PI PALANKER, DANIEL V · 2017 to 2021
$3.3M
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY027786
6 · The paper itself

Abstract

Photovoltaic subretinal prosthesis (PRIMA) enables restoration of sight via electrical stimulation of the interneurons in degenerated retina, with resolution limited by the 100 μm pixel size. Since decreasing the pixel size below 75 μm in the current bipolar geometry is impossible, we explore the possibility of using smaller pixels based on a novel 3-dimensional honeycomb-shaped design. We assessed the long-term biocompatibility and stability of these arrays in rats by investigating the anatomical integration of the retina with flat and 3D implants and response to electrical stimulation over lifetime - up to 9 months post-implantation in aged rats. With both flat and 3D implants, VEP amplitude decreased after the day of implantation by more than 3-fold, and gradually recovered over about 3 months. With 25 µm high honeycomb walls, the majority of bipolar cells migrate into the wells, while amacrine and ganglion cells remain above the cavities, which is essential for selective network-mediated stimulation of the second-order neurons. Retinal thickness and full-field stimulation threshold with 40 µm-wide honeycomb pixels were comparable to those with planar devices - 0.05 mW/mm

Identifiers

PMID37546971
PMCPMC10402070
OpenAlexW4385334625

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.