Evidence map›Paper›PMID 37546947›Full record

ArticleResearch square2023

Synergistic effects of nanosecond pulsed plasma and electric field on inactivation of pancreatic cancer cells in vitro.

Edwin A Oshin, Zobia Minhas, Ruben M L Colunga Biancatelli, John D Catravas, Richard Heller, Siqi Guo, Chunqi Jiang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Edwin A OshinFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23455 USA.
Zobia MinhasFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23455 USA.
Ruben M L Colunga BiancatelliFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23455 USA.
John D CatravasFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23455 USA.
Richard HellerDepartment of Medical Engineering, University of South Florida, FL-33612 Tampa, USA.
Siqi GuoFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23455 USA.
Chunqi JiangFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23455 USA.

Funding

Controlled Delivery of Plasmid DNA via Low-Temperature Ion DepositionR01EB023878 · NIBIB · UNIVERSITY OF SOUTH FLORIDA · PI HELLER, RICHARD · 2018 to 2022
$1.7M
NIBIB NIH HHS R01 EB023878
6 · The paper itself

Abstract

Nanosecond pulsed atmospheric pressure plasma jets (ns-APPJs) produce reactive plasma species, including charged particles and reactive oxygen and nitrogen species (RONS), which can induce oxidative stress in biological cells. Nanosecond pulsed electric field (nsPEF) has also been found to cause permeabilization of cell membranes and induce apoptosis or cell death. Combining the treatment of ns-APPJ and nsPEF may enhance the effectiveness of cancer cell inactivation with only moderate doses of both treatments. Employing ns-APPJ powered by 9 kV, 200 ns pulses at 2 kHz and 60-nsPEF of 50 kV/cm at 1 Hz, the synergistic effects on pancreatic cancer cells (Pan02)

Identifiers

PMID37546947
PMCPMC10402252

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.