Evidence map›Paper›PMID 37546938›Full record

ArticlebioRxiv : the preprint server for biology2023

APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.

Michael S Haney, Róbert Pálovics, Christy Nicole Munson, Chris Long, Patrik Johansson, Oscar Yip, Wentao Dong, Eshaan Rawat, Elizabeth West, Johannes Cm Schlachetzki and 18 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 19 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 7 institutions in 1 country.

Michael S HaneyDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Róbert PálovicsDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Christy Nicole MunsonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Chris LongDepartment of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA.
Patrik JohanssonDepartment of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA.
Oscar YipGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.
Wentao DongThe Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.
Eshaan RawatThe Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.
Elizabeth WestDepartment of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Johannes Cm SchlachetzkiDepartment of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Andy TsaiDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ian Hunter GuldnerDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bhawika S LamichhaneDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Amanda SmithDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Nicholas SchaumDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kruti CalcuttawalaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Andrew ShinDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yung-Hua WangGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.
Chengzhong WangGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.
Nicole KoutsodendrisGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.
Geidy E SerranoLaboratory of Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA.
Thomas G BeachBanner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, AZ, USA.
Eric M ReimanBanner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, AZ, USA.
Christopher K GlassDevelopment and Stem Cell Biology Graduate Program, University of California, San Francisco, US.
Monther Abu-RemailehThe Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.
Annika EnejderDepartment of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA.
Yadong HuangGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Neurosciences Institute · USStanford University · USGladstone Institutes · USAlzheimer's Association · USUniversity of California San Diego · USBanner Sun Health Research Institute · USUniversity of California, San Francisco · US

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Steven Dyal Edland · 2019 to 2026
$34.9M
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI GONZALEZ HERNANDEZ, GRACIELA · 2001 to 2020
$32.5M
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Jennifer Kaci Fairchild · 2020 to 2026
$29.0M
APOE in the Predisposition to, Protection from and Prevention of Alzheimer's DiseaseR01AG069453 · NIA · BANNER HEALTH · PI ASHTON, NICHOLAS, LANGBAUM, JESSICA BROOKE · 2020 to 2025
$27.4M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI HEATHER Allyson BIMONTE-NELSON · 2021 to 2026
$24.9M
Project 4: Cross-species Dissection of Cellular Response to APOE Genotype and AD Pathology Using Single-cell Multi-omicsP01AG073082 · NIA · J. DAVID GLADSTONE INSTITUTES · PI MUCKE, LENNART · 2021 to 2025
$23.4M
Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
National Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8M
Stanford Medicine Center for Longevity and Healthy Aging Research Education CoreP30AG059307 · NIA · STANFORD UNIVERSITY · PI ZOU, JAMES · 2018 to 2025
$4.9M
Microglial lipid droplets in Alzheimer's diseaseRF1AG064928 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2019 to 2019
$3.7M
Multidisciplinary training in basic and translational Alzheimer's disease researchT32AG066596 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 2020 to 2024
$2.2M
Imaging the metabolic and phagocytic landscape of microglia in Alzheimer’s diseaseR03AG071791 · NIA · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C · 2021 to 2022
$315k
NIA NIH HHS P01 AG073082NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG059307NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG069453NIA NIH HHS R03 AG071791NIA NIH HHS RF1 AG064928NIA NIH HHS T32 AG000266NIA NIH HHS T32 AG066596NINDS NIH HHS U24 NS072026
6 · The paper itself

Abstract

Several genetic risk factors for Alzheimer's Disease (AD) implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells. However, the relationship between lipid metabolism in glia and AD pathology remains poorly understood. Through single-nucleus RNA-sequencing of AD brain tissue, we have identified a microglial state defined by the expression of the lipid droplet (LD) associated enzyme

Identifiers

PMID37546938
PMCPMC10401952
OpenAlexW4385237937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.