Evidence map›Paper›PMID 37546929›Full record

ArticlebioRxiv : the preprint server for biology2024

Functional analysis of cyclic diguanylate-modulating proteins in

Ruth Y Isenberg, Chandler S Holschbach, Jing Gao, Mark J Mandel

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ruth Y IsenbergDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI USA.ORCID 0000-0002-5415-940X
Chandler S HolschbachDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI USA.
Jing GaoDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.
Mark J MandelDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI USA.ORCID 0000-0001-6506-6711
University of Wisconsin–Madison · USNorthwestern University · US

Funding

GRADUATE TRAINING IN MOLECULAR BIOSCIENCEST32GM007215 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 1985 to 2018
$22.5M
Genetic analysis of beneficial bacterial colonizationR35GM148385 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Mark J Mandel · 2023 to 2026
$1.8M
NIGMS NIH HHS R35 GM148385NIGMS NIH HHS T32 GM007215
6 · The paper itself

Abstract

As bacterial symbionts transition from a motile free-living state to a sessile biofilm state, they must coordinate behavior changes suitable to each lifestyle. Cyclic diguanylate (c-di-GMP) is an intracellular signaling molecule that can regulate this transition, and it is synthesized by diguanylate cyclase (DGC) enzymes and degraded by phosphodiesterase (PDE) enzymes. Generally, c-di-GMP inhibits motility and promotes biofilm formation. While c-di-GMP and the enzymes that contribute to its metabolism have been well-studied in pathogens, considerably less focus has been placed on c-di-GMP regulation in beneficial symbionts.

Indexed as

biofilmc-di-GMPflagellar motilityVibrio fischeri

Identifiers

PMID37546929
PMCPMC10402110
OpenAlexW4385241893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.