Evidence map›Paper›PMID 37546919›Full record

ArticleResearch square2023

Chloroplast transformation for bioencapsulation and oral delivery using the immunoglobulin G fragment crystallizable (Fc) domain.

Lisa LaManna, Chih-Hsuan Chou, Hanqin Lei, Elisabeth R Barton, Pal Maliga

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lisa LaMannaWaksman Institute of Microbiology, Rutgers University, Piscataway, NJ 08854, USA.
Chih-Hsuan ChouDepartment of Applied Physiology & Kinesiology, University of Florida, College of Health and Human Performance, Gainesville, FL, 32611, USA.
Hanqin LeiDepartment of Applied Physiology & Kinesiology, University of Florida, College of Health and Human Performance, Gainesville, FL, 32611, USA.
Elisabeth R BartonDepartment of Applied Physiology & Kinesiology, University of Florida, College of Health and Human Performance, Gainesville, FL, 32611, USA.
Pal MaligaWaksman Institute of Microbiology, Rutgers University, Piscataway, NJ 08854, USA.
University of Florida · USRutgers, The State University of New Jersey · US

Funding

The Chloroplast Expression System as a platform for orally bioavailable muscle therapeuticsR21AR074271 · NIAMS · UNIVERSITY OF FLORIDA · PI BARTON, ELISABETH R · 2019 to 2020
$384k
NIAMS NIH HHS R21 AR074271
6 · The paper itself

Abstract

Proinsulin Like Growth Factor (prolGF1) and myostatin (Mstn) regulate muscle regeneration when intravenously delivered. We set out to test if chloroplast bioencapsulated forms of these proteins may serve as a non-invasive means of drug delivery through the digestive system. We created tobacco (

Identifiers

PMID37546919
PMCPMC10402193
OpenAlexW4385273522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.