Evidence map›Paper›PMID 37546908›Full record

ArticlebioRxiv : the preprint server for biology2023

Signaling specificity and kinetics of the human metabotropic glutamate receptors.

Tyler W McCullock, Loren P Cardani, Paul J Kammermeier

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tyler W McCullockDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0003-1628-1102
Loren P CardaniDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642.
Paul J KammermeierDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0002-8191-2284
University of Rochester Medical Center · US

Funding

A novel system for controlling dimeric receptor composition to discover unique heterodimer pharmacologyR01MH125849 · NIMH · UNIVERSITY OF ROCHESTER · PI KAMMERMEIER, PAUL J. · 2023 to 2025
$1.2M
New Tools for Studying Receptor DimersR21NS126779 · NINDS · UNIVERSITY OF ROCHESTER · PI KAMMERMEIER, PAUL J., LUECK, JOHN D. · 2022 to 2023
$407k
Tools for studying the regulation of Homer protein splicingR03NS124987 · NINDS · UNIVERSITY OF ROCHESTER · PI KAMMERMEIER, PAUL J. · 2021 to 2021
$154k
NIMH NIH HHS R01 MH125849NINDS NIH HHS R03 NS124987NINDS NIH HHS R21 NS126779
6 · The paper itself

Abstract

Metabotropic glutamate receptors (mGluRs) are obligate dimer G protein coupled receptors that can all function as homodimers. Here, each mGluR homodimer was examined for its G protein coupling profile using a BRET based assay that detects the interaction between a split YFP-tagged Gβ

Identifiers

PMID37546908
PMCPMC10402105
OpenAlexW4385619715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.