Evidence map›Paper›PMID 37546887›Full record

ArticlebioRxiv : the preprint server for biology2023

TGF-β broadly modifies rather than specifically suppresses reactivated memory CD8 T cells in a dose-dependent manner.

Alexis Taber, Andrew Konecny, James Scott-Browne, Martin Prlic

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Alexis TaberFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA.
Andrew KonecnyFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA.
James Scott-BrowneDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206.
Martin PrlicFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA.
University of Washington · USFred Hutch Cancer Center · USNational Jewish Health · US

Funding

Inflammation-driven T Cell Responses and their Dichotomous Effect on Host ImmunityR01AI123323 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRLIC, MARTIN · 2017 to 2025
$5.0M
Transcriptional Control of T Cell FunctionR01AI151021 · NIAID · NATIONAL JEWISH HEALTH · PI SCOTT-BROWNE, JAMES · 2021 to 2025
$2.0M
NIAID NIH HHS R01 AI123323NIAID NIH HHS R01 AI151021
6 · The paper itself

Abstract

Transforming growth factor β (TGF-β) directly acts on naïve, effector and memory T cells to control cell fate decisions, which was shown using genetic abrogation of TGF-β signaling. TGF-β availability is altered by infections and cancer, however the dose-dependent effects of TGF-β on memory CD8 T cell (T

Indexed as

ATAC-seqCCR8effector functionmemoryRNA-seqT cellTGF-βtranscriptome

Identifiers

PMID37546887
PMCPMC10402134
OpenAlexW4385375229

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.