Evidence map›Paper›PMID 37546870›Full record

ArticlebioRxiv : the preprint server for biology2023

Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice.

Raniki Kumari, Raluca Pascalau, Hui Wang, Sheetal Bajpayi, Maria Yurgel, Kwaku Quansah, Samer Hattar, Emmanouil Tampakakis, Rejji Kuruvilla

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Raniki KumariDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, 21218, USA.
Raluca PascalauDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, 21218, USA.
Hui WangSection on Light and Circadian Rhythms, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, 20892, USA.
Sheetal BajpayiDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
Maria YurgelSection on Light and Circadian Rhythms, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, 20892, USA.
Kwaku QuansahDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, 21218, USA.
Samer HattarSection on Light and Circadian Rhythms, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, 20892, USA.
Emmanouil TampakakisDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
Rejji KuruvillaDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, 21218, USA.
Johns Hopkins University · USNational Institutes of Health · US

Funding

Neuron-satellite glia interactions in the sympathetic nervous systemR01NS133423 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Rejji Kuruvilla · 2023 to 2026
$2.3M
Coupled axonal protein synthesis and lipidation in axon growth and homeostasisR01NS114478 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2020 to 2024
$2.2M
Neurotrophic factor trafficking and signaling in development and diseaseR01NS107342 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2019 to 2022
$1.7M
NINDS NIH HHS R01 NS107342NINDS NIH HHS R01 NS114478NINDS NIH HHS R01 NS133423
6 · The paper itself

Abstract

Neuropeptide Y (NPY) is best known for its effects in the brain as an orexigenic and anxiolytic agent and in reducing energy expenditure. NPY is also co-expressed with Norepinephrine (NE) in sympathetic neurons. Although NPY is generally considered to modulate noradrenergic responses, its specific roles in autonomic physiology remain under-appreciated. Here, we show that sympathetic-derived NPY is essential for metabolic and cardiovascular regulation in mice. NPY and NE are co-expressed in 90% of prevertebral sympathetic neurons and only 43% of paravertebral neurons. NPY-expressing neurons primarily innervate blood vessels in peripheral organs. Sympathetic-specific deletion of NPY elicits pronounced metabolic and cardiovascular defects in mice, including reductions in insulin secretion, glucose tolerance, cold tolerance, pupil size, and an elevation in heart rate, while notably, however, basal blood pressure was unchanged. These findings provide new knowledge about target tissue-specific functions of NPY derived from sympathetic neurons and imply its potential involvement in metabolic and cardiovascular diseases.

Identifiers

PMID37546870
PMCPMC10402010
OpenAlexW4385402259

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.