Evidence map›Paper›PMID 37546821›Full record

ArticleResearch square2023

Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoprotein.

Jinhee Park, Hyosung Kim, Leen Alabdalla, Smriti Mishra, Hassane Mchaourab

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jinhee ParkVanderbilt University.
Hyosung KimVanderbilt University.
Leen AlabdallaVanderbilt University.
Smriti MishraVanderbilt University.
Hassane MchaourabVanderbilt University.
Vanderbilt University · US

Funding

MOLECULAR BASIS OF LENS TRANSPARENCYR01EY012018 · NEI · VANDERBILT UNIVERSITY · PI MCHAOURAB, HASSANE S · 2003 to 2023
$10.4M
Structural dynamics of peptide-translocating ABC transportersR01GM128087 · NIGMS · VANDERBILT UNIVERSITY · PI MCHAOURAB, HASSANE S · 2019 to 2022
$1.7M
MOLECULAR BASIS OF LENS TRANSPARENCYR29EY012018 · NEI · VANDERBILT UNIVERSITY · PI MCHAOURAB, HASSANE S · 1998 to 2002
$291k
NEI NIH HHS R01 EY012018NEI NIH HHS R29 EY012018NIGMS NIH HHS R01 GM128087
6 · The paper itself

Abstract

The ATP-binding cassette subfamily B member 1 (ABCB1), encoding a multidrug transporter referred to as P-glycoprotein (Pgp), plays a critical role in the efflux of xenobiotics in humans and is implicated in cancer resistance to chemotherapy. Therefore, developing high throughput animal models to screen for Pgp function and bioavailability of substrates and inhibitors is paramount. Here, we generated and validated a zebrafish knockout line of

Identifiers

PMID37546821
PMCPMC10402247
OpenAlexW4385323845

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.