Evidence map›Paper›PMID 37546815›Full record

ArticleResearch square2023

Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage.

Rhiannon Aguilar, Laiba Khan, Nina Arslanovic, Kaylah Birmingham, Kritika Kasliwal, Spike Posnikoff, Ujani Chakraborty, Allison R Hickman, Rachel Watson, Ryan J Ezell and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Rhiannon AguilarWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.ORCID 0000-0001-5723-608X
Laiba KhanEpiCypher Inc., Durham, NC 27709, USA.
Nina ArslanovicWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Kaylah BirminghamWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Kritika KasliwalWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Spike PosnikoffWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Ujani ChakrabortyWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Allison R HickmanEpiCypher Inc., Durham, NC 27709, USA.ORCID 0009-0007-7901-6687
Rachel WatsonEpiCypher Inc., Durham, NC 27709, USA.
Ryan J EzellEpiCypher Inc., Durham, NC 27709, USA.
Hannah E WillisEpiCypher Inc., Durham, NC 27709, USA.
Martis W CowlesEpiCypher Inc., Durham, NC 27709, USA.
Richard GarnerWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Abraham ShimWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Ignacio GutierrezWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Matthew R MarundeEpiCypher Inc., Durham, NC 27709, USA.
Michael-Christopher KeoghEpiCypher Inc., Durham, NC 27709, USA.ORCID 0000-0002-2219-8623
Jessica K TylerWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Cornell University · USEpiCypher (United States) · US

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Chromatin's Role in Repair of Radiation-induced Damage.R01CA095641 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI TYLER, JESSICA K · 2002 to 2023
$5.2M
Development of efficient quantitative chromatin profiling in kit and high-throughput formatsR44HG010640 · NHGRI · EPICYPHER, INC. · PI KEOGH, MICHAEL-CHRISTOPHER, VENTERS, BRYAN J · 2020 to 2022
$2.4M
Discovering how autophagy is sufficient to extend yeast replicative lifespan (SUPPLEMENT)R01AG079883 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jessica K Tyler · 2023 to 2026
$2.2M
Novel pathways that regulate DNA double-strand break repair events in mammalian cellsR35GM139816 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TYLER, JESSICA K · 2021 to 2025
$2.1M
Accelerated discovery of methylation targeted therapeutic developmentR44CA212733 · NCI · EPICYPHER, INC. · PI SUN, ZU-WEN · 2018 to 2019
$2.1M
Multiplex nucleosome-based profiling for the development of next-generation chromatin labeling reagentsR44GM136172 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2020 to 2021
$1.8M
High-throughput methyltransferase assays using recombinant nucleosome substratesR44GM117683 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2018 to 2019
$1.7M
NCI NIH HHS R01 CA095641NCI NIH HHS R44 CA212733NHGRI NIH HHS R44 HG010640NIA NIH HHS R01 AG079883NIGMS NIH HHS R35 GM139816NIGMS NIH HHS R44 GM117683NIGMS NIH HHS R44 GM136172NIGMS NIH HHS T32 GM007739
6 · The paper itself

Abstract

Tardigrades are remarkable in their ability to survive extreme environments. The damage suppressor (Dsup) protein is thought responsible for their extreme resistance to reactive oxygen species (ROS) generated by irradiation. Here we show that expression of

Identifiers

PMID37546815
PMCPMC10402244
OpenAlexW4385348327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.