Evidence map›Paper›PMID 37546797›Full record

ArticlebioRxiv : the preprint server for biology2025

Optogenetic Stimulation of Single Ganglion Cells in the Living Primate Fovea.

Peter J Murphy, Juliette E McGregor, Zhengyang Xu, Qiang Yang, William Merigan, David R Williams

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Peter J MurphyThe Institute of Optics, University of Rochester, Rochester, New York.ORCID 0000-0002-9885-7779
Juliette E McGregorCenter for Visual Science, University of Rochester, Rochester, New York.ORCID 0000-0002-8046-028X
Zhengyang XuThe Institute of Optics, University of Rochester, Rochester, New York.
Qiang YangCenter for Visual Science, University of Rochester, Rochester, New York.
William MeriganThe Institute of Optics, University of Rochester, Rochester, New York.ORCID 0000-0002-9359-5538
David R WilliamsThe Institute of Optics, University of Rochester, Rochester, New York.ORCID 0000-0003-3227-8333
University of Rochester · US

Funding

VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI Susana Marcos · 1985 to 2026
$17.5M
Physiological and perceptual examination of vision restoration R01EY021166 · NEI · UNIVERSITY OF ROCHESTER · PI MERIGAN, WILLIAM H · 2011 to 2023
$8.4M
High Resolution Mapping of Foveal Ganglion Cell Receptive Fields in the Living Primate EyeR01EY031467 · NEI · UNIVERSITY OF ROCHESTER · PI DAVID R WILLIAMS · 2021 to 2026
$3.5M
NEI NIH HHS P30 EY001319NEI NIH HHS R01 EY021166NEI NIH HHS R01 EY031467
6 · The paper itself

Abstract

Though the responses of the rich variety of retinal ganglion cells (RGCs) reflect the totality of visual processing in the retina and provide the sole conduit for those processed responses to the brain, we have much to learn about how the brain uses these signals to guide behavior. An impediment to developing a comprehensive understanding of the role of retinal circuits in behavior is the paucity of causal studies in the intact primate visual system. Here we demonstrate the ability to optogenetically activate individual RGCs with flashes of light focused on single RGC somas

Identifiers

PMID37546797
PMCPMC10401937
OpenAlexW4385238839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.