Evidence map›Paper›PMID 37546790›Full record

ArticlebioRxiv : the preprint server for biology2023

Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling.

Anna M R Hayes, Logan Tierno Lauer, Alicia E Kao, Shan Sun, Molly E Klug, Linda Tsan, Jessica J Rea, Keshav S Subramanian, Cindy Gu, Natalie Tanios and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Anna M R HayesHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Logan Tierno LauerHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Alicia E KaoHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Shan SunDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.
Molly E KlugHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Linda TsanHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Jessica J ReaHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Keshav S SubramanianHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Cindy GuHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Natalie TaniosHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Arun AhujaHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Kristen N DonohueHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Léa Décarie-SpainHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Anthony A FodorDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.
Scott E KanoskiHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
University of Southern California · USUniversity of North Carolina at Charlotte · US

Funding

Higher-Order Neural Control of Food IntakeR01DK104897 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KANOSKI, SCOTT EDWARD · 2015 to 2024
$4.3M
Interactions between diet and cognitionR01DK123423 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Scott Edward Kanoski · 2019 to 2026
$3.4M
Neurobiological mechanisms of Western diet-induced cognitive dysfunctionF32AG077932 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAYES, ANNA MARIE ROSE · 2022 to 2024
$185k
NIA NIH HHS F32 AG077932NIDDK NIH HHS R01 DK104897NIDDK NIH HHS R01 DK123423
6 · The paper itself

Abstract

Western diet (WD) consumption during development yields long-lasting memory impairments, yet the underlying neurobiological mechanisms remain elusive. Here we developed an early life WD rodent model to evaluate whether dysregulated hippocampus (HPC) acetylcholine (ACh) signaling, a pathology associated with memory impairment in human dementia, is causally-related to WD-induced cognitive impairment. Rats received a cafeteria-style WD (access to various high-fat/high-sugar foods; CAF) or healthy chow (CTL) during the juvenile and adolescent periods (postnatal days 26-56). Behavioral, metabolic, and microbiome assessments were performed both before and after a 30-day healthy diet intervention beginning at early adulthood. Results revealed CAF-induced HPC-dependent contextual episodic memory impairments that persisted despite healthy diet intervention, whereas CAF was not associated with long-term changes in body weight, body composition, glucose tolerance, anxiety-like behavior, or gut microbiome. HPC immunoblot analyses after the healthy diet intervention identified reduced levels of vesicular ACh transporter in CAF vs. CTL rats, indicative of chronically reduced HPC ACh tone. To determine whether these changes were functionally related to memory impairments, we evaluated temporal HPC ACh binding via ACh-sensing fluorescent reporter

Identifiers

PMID37546790
PMCPMC10401939
OpenAlexW4385254876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.