Evidence map›Paper›PMID 37546781›Full record

ArticlebioRxiv : the preprint server for biology2024

Investigating the basis of lineage decisions and developmental trajectories in the dorsal spinal cord through pseudotime analyses.

Sandeep Gupta, Eric Heinrichs, Bennett G Novitch, Samantha J Butler

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Sandeep Gupta
Eric Heinrichs
Bennett G NovitchORCID 0000-0002-2696-3708
Samantha J ButlerORCID 0000-0002-9491-7551
University of California, Los Angeles · US

Funding

UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani, SUMA JACOB · 2020 to 2026
$9.6M
Assessing the mechanisms directing cell fate in the dorsal spinal cordR01NS123187 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAMANTHA J BUTLER · 2022 to 2026
$2.2M
Diverse roles of the Bone Morphogenetic Proteins in the developing spinal cordR01NS085097 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUTLER, SAMANTHA J · 2014 to 2018
$1.7M
NICHD NIH HHS P50 HD103557NINDS NIH HHS R01 NS085097NINDS NIH HHS R01 NS123187
6 · The paper itself

Abstract

Dorsal interneurons (dIs) in the spinal cord encode the perception of touch, pain, heat, itch, and proprioception. While previous studies using genetic strategies in animal models have revealed important insights into dI development, the molecular details by which dIs arise as distinct populations of neurons remain incomplete. We have developed a resource to investigate dI fate specification by combining a single-cell RNA-Seq atlas of mouse ESC-derived dIs with pseudotime analyses. To validate this Summary statement: Pseudotime analyses of embryonic stem cell-derived dorsal spinal interneurons reveals both novel regulators and lineage relationships between different interneuron populations.

Identifiers

PMID37546781
PMCPMC10402035
OpenAlexW4385286931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.