Evidence map›Paper›PMID 37546332›Full record

SynthesisFrontiers in public health2023

Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers.

Amit Bansal, Mai-Chi Trieu, Kristin G I Mohn, Anders Madsen, Jan Stefan Olofsson, Helene Heitmann Sandnes, Marianne Sævik, Hanne Søyland, Lena Hansen, Therese Bredholt Onyango and 7 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Association between social activities and risk of COVID-19 in a cohort of healthcare personnel.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Amit BansalDepartment of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.
Mai-Chi TrieuDepartment of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.
Kristin G I MohnDepartment of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.
Anders MadsenDepartment of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.
Jan Stefan OlofssonDepartment of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.
Helene Heitmann SandnesDepartment of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.
Marianne SævikDepartment of Medicine, Haukeland University Hospital, Bergen, Norway.
Hanne SøylandDepartment of Medicine, Haukeland University Hospital, Bergen, Norway.
Lena HansenDepartment of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.
Therese Bredholt OnyangoDepartment of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.
Camilla TøndelDepartment of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.
Karl Albert BrokstadDepartment of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.
Bergen COVID-19 research group
Heidi SyreDepartment of Medical Microbiology, Stavanger University Hospital, Stavanger, Norway.
Åse Garløv RiisDepartment of Medicine, Stavanger University Hospital, Stavanger, Norway.
Nina LangelandDepartment of Medicine, Haukeland University Hospital, Bergen, Norway.
Rebecca Jane CoxDepartment of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Preventing infection in healthcare workers (HCWs) is crucial for protecting healthcare systems during the COVID-19 pandemic. Here, we investigated the seroepidemiology of SARS-CoV-2 in HCWs in Norway with low-transmission settings. Methods: From March 2020, we recruited HCWs at four medical centres. We determined infection by SARS-CoV-2 RT-PCR and serological testing and evaluated the association between infection and exposure variables, comparing our findings with global data in a meta-analysis. Anti-spike IgG antibodies were measured after infection and/or vaccination in a longitudinal cohort until June 2021. Results: We identified a prevalence of 10.5% (95% confidence interval, CI: 8.8-12.3) in 2020 and an incidence rate of 15.0 cases per 100 person-years (95% CI: 12.5-17.8) among 1,214 HCWs with 848 person-years of follow-up time. Following infection, HCWs ( Conclusion: We found high and modest risks of SARS-CoV-2 infection with household and occupational exposure, respectively, in HCWs, suggesting the need to strengthen infection prevention strategies within households and medical centres. Infection generated long-lasting antibodies in most HCWs; therefore, we support delaying COVID-19 vaccination in primed HCWs, prioritising the non-infected high-risk HCWs amid vaccine shortage.

Indexed as

COVID-19SARS-CoV-2Antibody FormationBNT162 VaccineChAdOx1 nCoV-19COVID-19 VaccinesHealth PersonnelHumansImmunoglobulin GPandemicsRisk AssessmentSeroepidemiologic StudiesBNT162 VaccineChAdOx1 nCoV-19COVID-19 VaccinesImmunoglobulin GantibodiesCOVID-19healthcare workershouseholdoccupationalSARS-CoV-2spike protein

Identifiers

PMID37546332
PMCPMC10402899

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.