Evidence map›Paper›PMID 37546290›Full record

ReviewObesity science & practice2023

Offspring epigenetic markers at birth related to gestational BMI predict offspring BMI-trajectories from infancy to 26 years.

Vimala Devi Janjanam, Susan Ewart, Hongmei Zhang, Yu Jiang, Hasan Arshad, Ali H Ziyab, Wilfried Karmaus

Abstract readReview
In one paragraph

Review in Obesity science & practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vimala Devi JanjanamDivision of Epidemiology, Biostatistics, and Environmental Health School of Public Health University of Memphis Memphis Tennessee USA.ORCID https://orcid.org/0000-0001-9279-0625
Susan EwartDepartment of Large Animal Clinical Sciences Michigan State University East Lansing Michigan USA.
Hongmei ZhangDivision of Epidemiology, Biostatistics, and Environmental Health School of Public Health University of Memphis Memphis Tennessee USA.
Yu JiangDivision of Epidemiology, Biostatistics, and Environmental Health School of Public Health University of Memphis Memphis Tennessee USA.
Hasan ArshadFaculty of Medicine Clinical and Experimental Sciences University of Southampton Southampton UK.
Ali H ZiyabFaculty of Medicine Department of Community and Behavioral Sciences Kuwait University Safat Kuwait.
Wilfried KarmausDivision of Epidemiology, Biostatistics, and Environmental Health School of Public Health University of Memphis Memphis Tennessee USA.

Funding

Does epigenetic methylation explain the gender-switch in adolescent asthma?R01AI121226 · NIAID · UNIVERSITY OF MEMPHIS · PI HOLLOWAY, JOHN W, ZHANG, HONGMEI · 2016 to 2020
$3.2M
Effect of Prenatal Compounds on Adult Lung Function via Neonatal DNA MethylationR01HL132321 · NHLBI · UNIVERSITY OF MEMPHIS · PI KARMAUS, WILFRIED JJ · 2016 to 2020
$3.2M
Transgenerational epigenetic inheritance of allergy in a multigenerational cohortR01AI091905 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KARMAUS, WILFRIED JJ · 2011 to 2015
$2.7M
Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescenceR01HL082925 · NHLBI · ST. MARY'S HOSPITAL NEWPORT · PI ARSHAD, SYED HASAN · 2007 to 2010
$1.7M
NHLBI NIH HHS R01 HL082925NHLBI NIH HHS R01 HL132321NIAID NIH HHS R01 AI091905NIAID NIH HHS R01 AI121226
6 · The paper itself

Abstract

Objective: To date, epigenetic studies identified differential DNA methylation (DNAm) related to gestational-body mass index (BMI) in offspring at birth. This study investigated whether the identified DNAm in offspring were also associated with BMI trajectories from infancy to age 26 years. Methods: Data of 794 participants from Isle of Wight birth cohort in UK were investigated to study association between BMI trajectories and DNAm related to gestational-BMI at birth. Multinominal logistic regression models were applied to test the association between 1090 DNAm sites reported in three prior epigenome-wide association studies and BMI trajectories. Results: DNAm site cg23089913 ( Conclusions: Deviations in methylation of cg23089913 (

Indexed as

epigeneticsNANOS1SOX14

Identifiers

PMID37546290
PMCPMC10399520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.