Evidence map›Paper›PMID 37545962›Full record

ArticleAfrican health sciences2023

Human herpesvirus-8 infection in Tunisian adult acute leukemia patients.

Imene Handous, Naila Hannachi, Bechir Achour, Manel Marzouk, Olfa Hazgui, Saloua Yacoub, Abderrahim Khelif, Jalel Boukadida

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Imene HandousUniversité de Sfax, Ecole nationale d'Ingénieurs de Sfax, 3038, Sfax, Tunisie.
Naila HannachiUniversité de Sousse, Faculté de Médecine de Sousse, Laboratoire de Microbiologie, UR12SP34, Hôpital Farhat Hached,4000, Sousse,Tunisie.
Bechir AchourUniversité de Sousse, Faculté de Médecine de Sousse, Service d'Hématologie, Hôpital Farhat Hached, 4000, Sousse, Tunisie.
Manel MarzoukUniversité de Sousse, Faculté de Médecine de Sousse, Laboratoire de Microbiologie, UR12SP34, Hôpital Farhat Hached,4000, Sousse,Tunisie.
Olfa HazguiUniversité de Sousse, Faculté de Médecine de Sousse, Laboratoire de Microbiologie, UR12SP34, Hôpital Farhat Hached,4000, Sousse,Tunisie.
Saloua YacoubCentre Régional de Transfusion Sanguine, Hôpital Farhat Hached,4000, Sousse,Tunisie.
Abderrahim KhelifUniversité de Sousse, Faculté de Médecine de Sousse, Service d'Hématologie, Hôpital Farhat Hached, 4000, Sousse, Tunisie.
Jalel BoukadidaUniversité de Sousse, Faculté de Médecine de Sousse, Laboratoire de Microbiologie, UR12SP34, Hôpital Farhat Hached,4000, Sousse,Tunisie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Human herpesvirus 8 (HHV-8) has been linked to the development of Kaposi's sarcoma (KS)and multiple other hematologic malignant disorders. However, the role of HHV-8 in acute leukemia patients is unknown. Objectives: The objective of this study was to determine the prevalence of HHV-8 in Tunisian acute leukemia patients and in healthy blood donors. Methods: An indirect immunofluorescence test was used to detect the presence of anti-HHV8 antibodies. Nested PCR was used for the detection of HHV-8 DNAemia in samples of plasma. Results: The seroprevalence of HHV-8 was significantly higher in acute leukemia patients (21,4% ,15/70) than in healthy blood donors (7,1%, 5/70), (p= 0.02). Gender, type of disease, status of disease, prior blood transfusion, and outcome were not associated with HHV-8 seroprevalence. However, among acute leukemia patients, HHV-8 seroprevalence was statistically associated with older age > 40 years of age, (p=0.002). HHV-8 DNAemia was detected (1,4%) in only one patient of acute myeloid leukemia (AML) and none of the healthy blood donors. Conclusions: The seroprevalence of HHV-8 infection in Tunisian adult acute leukemia patients was three times as high compared to healthy blood donors, suggesting that patients with acute leukemia might be at increased risk of HHV-8 infection.

Indexed as

Acquired Immunodeficiency SyndromeHerpesviridae InfectionsHerpesvirus 8, HumanLeukemia, Myeloid, AcuteSarcoma, KaposiAdultAntibodies, ViralHumansSeroepidemiologic StudiesAntibodies, Viralacute leukemia patientsblood donorsHuman herpesvirus 8prevalence

Identifiers

PMID37545962
PMCPMC10398449

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.